Sensitive determination of RDX, nitroso-RDX metabolites, and other munitions in ground water by solid-phase extraction and isotope dilution liquid chromatography-atmospheric pressure chemical ionization mass spectrometry

D. A. Cassada, S. J. Monson, Daniel D Snow, R. F. Spalding

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Recent improvements in the LC-MS interface have increased the sensitivity and selectivity of this instrument in the analysis of polar and thermally-labile aqueous constituents. Determination of RDX, nitroso-RDX metabolites, and other munitions was enhanced using LC-MS with solid-phase extraction, 15N3-RDX internal standard, and electrospray ionization (ESI) in negative ion mode. ESI produced a five-fold increase in detector response over atmospheric pressure chemical ionization (APCI) for the nitramine compounds, while the more energetic APCI produced more than twenty times the ESI response for nitroaromatics. Method detection limits in ESI for nitramines varied from 0.03 μgl-1 for MNX to 0.05 μgl-1 for RDX. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)87-95
Number of pages9
JournalJournal of Chromatography A
Volume844
Issue number1-2
DOIs
StatePublished - Jun 4 1999

Fingerprint

Electrospray ionization
Atmospheric Pressure
Solid Phase Extraction
Liquid chromatography
Groundwater
Metabolites
Liquid Chromatography
Isotopes
Dilution
Atmospheric pressure
Ionization
Mass spectrometry
Mass Spectrometry
Limit of Detection
Negative ions
Ions
Detectors
cyclonite
nitramine

Keywords

  • 1,3,5-Trinitro-1,3,5-triazacyclohexane
  • Explosives
  • Nitramines
  • Nitroaromatics
  • RDX

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

Cite this

@article{059a84f79f2d4f54acb1aebfa274e18d,
title = "Sensitive determination of RDX, nitroso-RDX metabolites, and other munitions in ground water by solid-phase extraction and isotope dilution liquid chromatography-atmospheric pressure chemical ionization mass spectrometry",
abstract = "Recent improvements in the LC-MS interface have increased the sensitivity and selectivity of this instrument in the analysis of polar and thermally-labile aqueous constituents. Determination of RDX, nitroso-RDX metabolites, and other munitions was enhanced using LC-MS with solid-phase extraction, 15N3-RDX internal standard, and electrospray ionization (ESI) in negative ion mode. ESI produced a five-fold increase in detector response over atmospheric pressure chemical ionization (APCI) for the nitramine compounds, while the more energetic APCI produced more than twenty times the ESI response for nitroaromatics. Method detection limits in ESI for nitramines varied from 0.03 μgl-1 for MNX to 0.05 μgl-1 for RDX. Copyright (C) 1999 Elsevier Science B.V.",
keywords = "1,3,5-Trinitro-1,3,5-triazacyclohexane, Explosives, Nitramines, Nitroaromatics, RDX",
author = "Cassada, {D. A.} and Monson, {S. J.} and Snow, {Daniel D} and Spalding, {R. F.}",
year = "1999",
month = "6",
day = "4",
doi = "10.1016/S0021-9673(99)00310-6",
language = "English (US)",
volume = "844",
pages = "87--95",
journal = "Journal of Chromatography A",
issn = "0021-9673",
number = "1-2",

}

TY - JOUR

T1 - Sensitive determination of RDX, nitroso-RDX metabolites, and other munitions in ground water by solid-phase extraction and isotope dilution liquid chromatography-atmospheric pressure chemical ionization mass spectrometry

AU - Cassada, D. A.

AU - Monson, S. J.

AU - Snow, Daniel D

AU - Spalding, R. F.

PY - 1999/6/4

Y1 - 1999/6/4

N2 - Recent improvements in the LC-MS interface have increased the sensitivity and selectivity of this instrument in the analysis of polar and thermally-labile aqueous constituents. Determination of RDX, nitroso-RDX metabolites, and other munitions was enhanced using LC-MS with solid-phase extraction, 15N3-RDX internal standard, and electrospray ionization (ESI) in negative ion mode. ESI produced a five-fold increase in detector response over atmospheric pressure chemical ionization (APCI) for the nitramine compounds, while the more energetic APCI produced more than twenty times the ESI response for nitroaromatics. Method detection limits in ESI for nitramines varied from 0.03 μgl-1 for MNX to 0.05 μgl-1 for RDX. Copyright (C) 1999 Elsevier Science B.V.

AB - Recent improvements in the LC-MS interface have increased the sensitivity and selectivity of this instrument in the analysis of polar and thermally-labile aqueous constituents. Determination of RDX, nitroso-RDX metabolites, and other munitions was enhanced using LC-MS with solid-phase extraction, 15N3-RDX internal standard, and electrospray ionization (ESI) in negative ion mode. ESI produced a five-fold increase in detector response over atmospheric pressure chemical ionization (APCI) for the nitramine compounds, while the more energetic APCI produced more than twenty times the ESI response for nitroaromatics. Method detection limits in ESI for nitramines varied from 0.03 μgl-1 for MNX to 0.05 μgl-1 for RDX. Copyright (C) 1999 Elsevier Science B.V.

KW - 1,3,5-Trinitro-1,3,5-triazacyclohexane

KW - Explosives

KW - Nitramines

KW - Nitroaromatics

KW - RDX

UR - http://www.scopus.com/inward/record.url?scp=0032993384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032993384&partnerID=8YFLogxK

U2 - 10.1016/S0021-9673(99)00310-6

DO - 10.1016/S0021-9673(99)00310-6

M3 - Article

C2 - 10399325

AN - SCOPUS:0032993384

VL - 844

SP - 87

EP - 95

JO - Journal of Chromatography A

JF - Journal of Chromatography A

SN - 0021-9673

IS - 1-2

ER -