Abstract
A vesicle in a cell is an enclosed structure in which the interior fluid is encompassed by a lipid bilayer. Synthetic vesicles are known as the liposomes. Liposomes with a single phospholipid bilayer are called unilamellar liposomes; otherwise, they are called multilamellar liposomes or onion-like liposomes (vesicles). One prototype synthetic onion-like vesicle, namely, onion-like dendrimersomes, have been recently produced via the self-assembly of amphiphilic Janus dendrimers (Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 1162). Herein, we show computer simulation evidence of another type of onion-like vesicle, namely, onion-like oligomersomes, via the self-assembly of amphiphilic Janus oligomers in water. Specifically, we investigate the minimum-sized oligomers (or minimalist model) that can give rise to the onion-like oligomersomes as well as the composition-dependent phase diagrams. Insights into the formation condition and formation process of the onion-like oligomersomes are obtained. We demonstrate that the discharge of the in-vesicle water is through the remarkable "peeling-one-onion-layer-at-a-time" fashion, a feature that can be utilized for a clinical dosing regimen. The ability to control the formation of onion-like oligomersomes by design can be exploited for applications in drug and gene delivery.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8026-8037 |
| Number of pages | 12 |
| Journal | ACS Nano |
| Volume | 10 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 23 2016 |
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Keywords
- dissipative particle dynamics
- hydrophobic interaction
- minimalist model
- onion-like vesicle
- self-assembly
ASJC Scopus subject areas
- Materials Science(all)
- Engineering(all)
- Physics and Astronomy(all)
Cite this
Self-Assembly of Janus Oligomers into Onion-like Vesicles with Layer-by-Layer Water Discharging Capability : A Minimalist Model. / Arai, Noriyoshi; Yasuoka, Kenji; Zeng, Xiao Cheng.
In: ACS Nano, Vol. 10, No. 8, 23.08.2016, p. 8026-8037.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Self-Assembly of Janus Oligomers into Onion-like Vesicles with Layer-by-Layer Water Discharging Capability
T2 - A Minimalist Model
AU - Arai, Noriyoshi
AU - Yasuoka, Kenji
AU - Zeng, Xiao Cheng
PY - 2016/8/23
Y1 - 2016/8/23
N2 - A vesicle in a cell is an enclosed structure in which the interior fluid is encompassed by a lipid bilayer. Synthetic vesicles are known as the liposomes. Liposomes with a single phospholipid bilayer are called unilamellar liposomes; otherwise, they are called multilamellar liposomes or onion-like liposomes (vesicles). One prototype synthetic onion-like vesicle, namely, onion-like dendrimersomes, have been recently produced via the self-assembly of amphiphilic Janus dendrimers (Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 1162). Herein, we show computer simulation evidence of another type of onion-like vesicle, namely, onion-like oligomersomes, via the self-assembly of amphiphilic Janus oligomers in water. Specifically, we investigate the minimum-sized oligomers (or minimalist model) that can give rise to the onion-like oligomersomes as well as the composition-dependent phase diagrams. Insights into the formation condition and formation process of the onion-like oligomersomes are obtained. We demonstrate that the discharge of the in-vesicle water is through the remarkable "peeling-one-onion-layer-at-a-time" fashion, a feature that can be utilized for a clinical dosing regimen. The ability to control the formation of onion-like oligomersomes by design can be exploited for applications in drug and gene delivery.
AB - A vesicle in a cell is an enclosed structure in which the interior fluid is encompassed by a lipid bilayer. Synthetic vesicles are known as the liposomes. Liposomes with a single phospholipid bilayer are called unilamellar liposomes; otherwise, they are called multilamellar liposomes or onion-like liposomes (vesicles). One prototype synthetic onion-like vesicle, namely, onion-like dendrimersomes, have been recently produced via the self-assembly of amphiphilic Janus dendrimers (Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 1162). Herein, we show computer simulation evidence of another type of onion-like vesicle, namely, onion-like oligomersomes, via the self-assembly of amphiphilic Janus oligomers in water. Specifically, we investigate the minimum-sized oligomers (or minimalist model) that can give rise to the onion-like oligomersomes as well as the composition-dependent phase diagrams. Insights into the formation condition and formation process of the onion-like oligomersomes are obtained. We demonstrate that the discharge of the in-vesicle water is through the remarkable "peeling-one-onion-layer-at-a-time" fashion, a feature that can be utilized for a clinical dosing regimen. The ability to control the formation of onion-like oligomersomes by design can be exploited for applications in drug and gene delivery.
KW - dissipative particle dynamics
KW - hydrophobic interaction
KW - minimalist model
KW - onion-like vesicle
KW - self-assembly
UR - http://www.scopus.com/inward/record.url?scp=84983434257&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983434257&partnerID=8YFLogxK
U2 - 10.1021/acsnano.6b04087
DO - 10.1021/acsnano.6b04087
M3 - Article
C2 - 27466700
AN - SCOPUS:84983434257
VL - 10
SP - 8026
EP - 8037
JO - ACS Nano
JF - ACS Nano
SN - 1936-0851
IS - 8
ER -