Self-Assembly of Janus Oligomers into Onion-like Vesicles with Layer-by-Layer Water Discharging Capability

A Minimalist Model

Noriyoshi Arai, Kenji Yasuoka, Xiao C Zeng

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A vesicle in a cell is an enclosed structure in which the interior fluid is encompassed by a lipid bilayer. Synthetic vesicles are known as the liposomes. Liposomes with a single phospholipid bilayer are called unilamellar liposomes; otherwise, they are called multilamellar liposomes or onion-like liposomes (vesicles). One prototype synthetic onion-like vesicle, namely, onion-like dendrimersomes, have been recently produced via the self-assembly of amphiphilic Janus dendrimers (Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 1162). Herein, we show computer simulation evidence of another type of onion-like vesicle, namely, onion-like oligomersomes, via the self-assembly of amphiphilic Janus oligomers in water. Specifically, we investigate the minimum-sized oligomers (or minimalist model) that can give rise to the onion-like oligomersomes as well as the composition-dependent phase diagrams. Insights into the formation condition and formation process of the onion-like oligomersomes are obtained. We demonstrate that the discharge of the in-vesicle water is through the remarkable "peeling-one-onion-layer-at-a-time" fashion, a feature that can be utilized for a clinical dosing regimen. The ability to control the formation of onion-like oligomersomes by design can be exploited for applications in drug and gene delivery.

Original languageEnglish (US)
Pages (from-to)8026-8037
Number of pages12
JournalACS Nano
Volume10
Issue number8
DOIs
StatePublished - Aug 23 2016

Fingerprint

Janus
Liposomes
oligomers
Oligomers
Self assembly
self assembly
Water
water
peeling
dendrimers
Dendrimers
genes
Unilamellar Liposomes
Lipid bilayers
Peeling
lipids
delivery
drugs
computerized simulation
prototypes

Keywords

  • dissipative particle dynamics
  • hydrophobic interaction
  • minimalist model
  • onion-like vesicle
  • self-assembly

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

Cite this

Self-Assembly of Janus Oligomers into Onion-like Vesicles with Layer-by-Layer Water Discharging Capability : A Minimalist Model. / Arai, Noriyoshi; Yasuoka, Kenji; Zeng, Xiao C.

In: ACS Nano, Vol. 10, No. 8, 23.08.2016, p. 8026-8037.

Research output: Contribution to journalArticle

@article{732019778bdd4154b84bcf7d0740e9ef,
title = "Self-Assembly of Janus Oligomers into Onion-like Vesicles with Layer-by-Layer Water Discharging Capability: A Minimalist Model",
abstract = "A vesicle in a cell is an enclosed structure in which the interior fluid is encompassed by a lipid bilayer. Synthetic vesicles are known as the liposomes. Liposomes with a single phospholipid bilayer are called unilamellar liposomes; otherwise, they are called multilamellar liposomes or onion-like liposomes (vesicles). One prototype synthetic onion-like vesicle, namely, onion-like dendrimersomes, have been recently produced via the self-assembly of amphiphilic Janus dendrimers (Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 1162). Herein, we show computer simulation evidence of another type of onion-like vesicle, namely, onion-like oligomersomes, via the self-assembly of amphiphilic Janus oligomers in water. Specifically, we investigate the minimum-sized oligomers (or minimalist model) that can give rise to the onion-like oligomersomes as well as the composition-dependent phase diagrams. Insights into the formation condition and formation process of the onion-like oligomersomes are obtained. We demonstrate that the discharge of the in-vesicle water is through the remarkable {"}peeling-one-onion-layer-at-a-time{"} fashion, a feature that can be utilized for a clinical dosing regimen. The ability to control the formation of onion-like oligomersomes by design can be exploited for applications in drug and gene delivery.",
keywords = "dissipative particle dynamics, hydrophobic interaction, minimalist model, onion-like vesicle, self-assembly",
author = "Noriyoshi Arai and Kenji Yasuoka and Zeng, {Xiao C}",
year = "2016",
month = "8",
day = "23",
doi = "10.1021/acsnano.6b04087",
language = "English (US)",
volume = "10",
pages = "8026--8037",
journal = "ACS Nano",
issn = "1936-0851",
publisher = "American Chemical Society",
number = "8",

}

TY - JOUR

T1 - Self-Assembly of Janus Oligomers into Onion-like Vesicles with Layer-by-Layer Water Discharging Capability

T2 - A Minimalist Model

AU - Arai, Noriyoshi

AU - Yasuoka, Kenji

AU - Zeng, Xiao C

PY - 2016/8/23

Y1 - 2016/8/23

N2 - A vesicle in a cell is an enclosed structure in which the interior fluid is encompassed by a lipid bilayer. Synthetic vesicles are known as the liposomes. Liposomes with a single phospholipid bilayer are called unilamellar liposomes; otherwise, they are called multilamellar liposomes or onion-like liposomes (vesicles). One prototype synthetic onion-like vesicle, namely, onion-like dendrimersomes, have been recently produced via the self-assembly of amphiphilic Janus dendrimers (Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 1162). Herein, we show computer simulation evidence of another type of onion-like vesicle, namely, onion-like oligomersomes, via the self-assembly of amphiphilic Janus oligomers in water. Specifically, we investigate the minimum-sized oligomers (or minimalist model) that can give rise to the onion-like oligomersomes as well as the composition-dependent phase diagrams. Insights into the formation condition and formation process of the onion-like oligomersomes are obtained. We demonstrate that the discharge of the in-vesicle water is through the remarkable "peeling-one-onion-layer-at-a-time" fashion, a feature that can be utilized for a clinical dosing regimen. The ability to control the formation of onion-like oligomersomes by design can be exploited for applications in drug and gene delivery.

AB - A vesicle in a cell is an enclosed structure in which the interior fluid is encompassed by a lipid bilayer. Synthetic vesicles are known as the liposomes. Liposomes with a single phospholipid bilayer are called unilamellar liposomes; otherwise, they are called multilamellar liposomes or onion-like liposomes (vesicles). One prototype synthetic onion-like vesicle, namely, onion-like dendrimersomes, have been recently produced via the self-assembly of amphiphilic Janus dendrimers (Proc. Natl. Acad. Sci. U.S.A. 2016, 113, 1162). Herein, we show computer simulation evidence of another type of onion-like vesicle, namely, onion-like oligomersomes, via the self-assembly of amphiphilic Janus oligomers in water. Specifically, we investigate the minimum-sized oligomers (or minimalist model) that can give rise to the onion-like oligomersomes as well as the composition-dependent phase diagrams. Insights into the formation condition and formation process of the onion-like oligomersomes are obtained. We demonstrate that the discharge of the in-vesicle water is through the remarkable "peeling-one-onion-layer-at-a-time" fashion, a feature that can be utilized for a clinical dosing regimen. The ability to control the formation of onion-like oligomersomes by design can be exploited for applications in drug and gene delivery.

KW - dissipative particle dynamics

KW - hydrophobic interaction

KW - minimalist model

KW - onion-like vesicle

KW - self-assembly

UR - http://www.scopus.com/inward/record.url?scp=84983434257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983434257&partnerID=8YFLogxK

U2 - 10.1021/acsnano.6b04087

DO - 10.1021/acsnano.6b04087

M3 - Article

VL - 10

SP - 8026

EP - 8037

JO - ACS Nano

JF - ACS Nano

SN - 1936-0851

IS - 8

ER -