Selenoproteins in the endoplasmic reticulum

Research output: Chapter in Book/Report/Conference proceedingChapter

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Abstract

The endoplasmic reticulum (ER) is an organelle which is present in all eukaryotic cells. The ER is a major compartment where protein folding, glycosylation, and disulfide bond formation occur. Selenocysteine containing proteins (selenoproteins) are a subgroup of thiol oxidoreductases. Recent studies demonstrated that 7 of 25 known human selenoproteins, Sep15, SelM, SelT, D2, SelS, SelK, and SelN, reside in the ER. Thus, ER-associated redox processes are dependent on selenoproteins, and consequently, on selenocysteine biosynthesis and overall selenium status of the cell. At the same time, ER selenoproteins include the least characterized human selenoproteins. In this chapter, we summarize recent results on the ER selenoproteome.

Original languageEnglish (US)
Title of host publicationSelenium: Its Molecular Biology and Role in Human Health
PublisherSpringer New York
Pages221-234
Number of pages14
Volume9781461410256
ISBN (Print)9781461410256, 146141024X, 9781461410249
DOIs
StatePublished - Jun 1 2012

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Selenoproteins
Selenocysteine
Endoplasmic Reticulum
Proteins
Glycosylation
Protein folding
Biosynthesis
Protein Folding
Eukaryotic Cells
Selenium
Sulfhydryl Compounds
Disulfides
Organelles
Oxidation-Reduction
Oxidoreductases

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Fomenko, D. (2012). Selenoproteins in the endoplasmic reticulum. In Selenium: Its Molecular Biology and Role in Human Health (Vol. 9781461410256, pp. 221-234). Springer New York. https://doi.org/10.1007/978-1-4614-1025-6_17

Selenoproteins in the endoplasmic reticulum. / Fomenko, Dmitri.

Selenium: Its Molecular Biology and Role in Human Health. Vol. 9781461410256 Springer New York, 2012. p. 221-234.

Research output: Chapter in Book/Report/Conference proceedingChapter

Fomenko, D 2012, Selenoproteins in the endoplasmic reticulum. in Selenium: Its Molecular Biology and Role in Human Health. vol. 9781461410256, Springer New York, pp. 221-234. https://doi.org/10.1007/978-1-4614-1025-6_17
Fomenko D. Selenoproteins in the endoplasmic reticulum. In Selenium: Its Molecular Biology and Role in Human Health. Vol. 9781461410256. Springer New York. 2012. p. 221-234 https://doi.org/10.1007/978-1-4614-1025-6_17
Fomenko, Dmitri. / Selenoproteins in the endoplasmic reticulum. Selenium: Its Molecular Biology and Role in Human Health. Vol. 9781461410256 Springer New York, 2012. pp. 221-234
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