Selective impairment in the recognition of anger induced by diazepam

Robert James Richard Blair, H. Valerie Curran

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

Rationale: Facial expressions appear to be processed by at least partially separable neuro-cognitive systems. Given this functional specialization of expression processing, it is plausible that these neurocognitive systems may also be dissociable pharmacologically. Objective: The present study therefore compared the effects of diazepam (15 mg) with placebo upon the ability to recognize emotional expressions. Methods: A double blind, independent group design was used to compare the effects of diazepam and matched placebo in 32 healthy volunteers. Participants were presented morphed facial expression stimuli following a paradigm developed for use with patients with brain damage and asked to name one of the six basic emotions (sadness, happiness, anger, disgust, fear and surprise). Results: Diazepam selectively impaired subjects' ability to recognize angry expressions but did not affect recognition of any other emotional expression. Conclusions: The findings are interpreted as providing further support for the suggestion that there are dissociable systems responsible for processing emotional expressions. It is suggested that these findings may have implications for understanding paradoxical aggression sometimes elicited by benzodiazepines.

Original languageEnglish (US)
Pages (from-to)335-338
Number of pages4
JournalPsychopharmacology
Volume147
Issue number3
DOIs
StatePublished - Dec 1 1999

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Keywords

  • Diazepam
  • Emotion
  • Emotional expression

ASJC Scopus subject areas

  • Pharmacology

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