Segregation analysis of hereditary nonpolyposis colorectal cancer

Joan E. Bailey‐Wilson, Robert C. Elston, Guy S. Schuelke, William Kimberling, William Albano, Jane F. Lynch, Henry T. Lynch

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Segregation analysis of eleven families comprising 2762 individuals indicated compatibility of the data with segregation of a major autosomal dominant gene for hereditary nonpolyposis colorectal cancer. It was estimated that between 71% and 79% of the gene carriers were susceptible and had age of onset that was normally distributed with mean about 47 and standard deviation about 10 years. There was a low frequency of sporadic cases at the older ages, a little less than four percent of nongene carriers being affected by age 80. No significant differences were found between the families exhibiting endometrial cancer (cancer family syndrome) and those not exhibiting endometrial cancer (hereditary site‐specific nonpolyposis colonic cancer).

Original languageEnglish (US)
Pages (from-to)27-38
Number of pages12
JournalGenetic Epidemiology
Volume3
Issue number1
DOIs
StatePublished - Jan 1 1986

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Hereditary Nonpolyposis Colorectal Neoplasms
Endometrial Neoplasms
Dominant Genes
Age of Onset
Colonic Neoplasms
Genes
Neoplasms

Keywords

  • cancer family syndrome
  • colon cancer
  • segregation analysis

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

Cite this

Bailey‐Wilson, J. E., Elston, R. C., Schuelke, G. S., Kimberling, W., Albano, W., Lynch, J. F., & Lynch, H. T. (1986). Segregation analysis of hereditary nonpolyposis colorectal cancer. Genetic Epidemiology, 3(1), 27-38. https://doi.org/10.1002/gepi.1370030104

Segregation analysis of hereditary nonpolyposis colorectal cancer. / Bailey‐Wilson, Joan E.; Elston, Robert C.; Schuelke, Guy S.; Kimberling, William; Albano, William; Lynch, Jane F.; Lynch, Henry T.

In: Genetic Epidemiology, Vol. 3, No. 1, 01.01.1986, p. 27-38.

Research output: Contribution to journalArticle

Bailey‐Wilson, JE, Elston, RC, Schuelke, GS, Kimberling, W, Albano, W, Lynch, JF & Lynch, HT 1986, 'Segregation analysis of hereditary nonpolyposis colorectal cancer', Genetic Epidemiology, vol. 3, no. 1, pp. 27-38. https://doi.org/10.1002/gepi.1370030104
Bailey‐Wilson JE, Elston RC, Schuelke GS, Kimberling W, Albano W, Lynch JF et al. Segregation analysis of hereditary nonpolyposis colorectal cancer. Genetic Epidemiology. 1986 Jan 1;3(1):27-38. https://doi.org/10.1002/gepi.1370030104
Bailey‐Wilson, Joan E. ; Elston, Robert C. ; Schuelke, Guy S. ; Kimberling, William ; Albano, William ; Lynch, Jane F. ; Lynch, Henry T. / Segregation analysis of hereditary nonpolyposis colorectal cancer. In: Genetic Epidemiology. 1986 ; Vol. 3, No. 1. pp. 27-38.
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