Segregating sustained attention from response inhibition in ADHD: An fMRI study

Soonjo Hwang, Harma Meffert, Ian Parsley, Patrick M. Tyler, Anna K. Erway, Mary L. Botkin, Kayla Pope, R. J.R. Blair

Research output: Contribution to journalArticle

Abstract

Background: The functional significance of the impairment shown by patients with ADHD on response inhibition tasks is unclear. Dysfunctional behavioral and BOLD responses to rare no-go cues might reflect disruption of response inhibition (mediating withholding the response) or selective attention (identifying the rare cue). However, a factorial go/no-go design (involving high and low frequency go and no-go stimuli) can disentangle these possibilities. Methods: Eighty youths [22 female, mean age = 13.70 (SD = 2.21), mean IQ = 104.65 (SD = 13.00); 49 with diagnosed ADHD] completed the factorial go/no-go task while undergoing fMRI. Results: There was a significant response type-by-ADHD symptom severity interaction within the left anterior insula cortex; increasing ADHD symptom severity was associated with decreased recruitment of this region to no-go cues irrespective of cue frequency. There was also a significant frequency-by-ADHD symptom severity interaction within the left superior frontal gyrus. ADHD symptom severity showed a quadratic relationship with responsiveness to low frequency cues (irrespective of whether these cues were go or no-go); within this region, at lower levels of symptom severity, increasing severity was associated with increased BOLD responses but at higher levels of symptom severity, decreasing BOLD responses. Conclusion: The current study reveals two separable forms of dysfunction that together probably contribute to the impairments shown by patients with ADHD on go/no-go tasks.

Original languageEnglish (US)
Article number101677
JournalNeuroImage: Clinical
Volume21
DOIs
StatePublished - 2019

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Cues
Magnetic Resonance Imaging
Prefrontal Cortex
Inhibition (Psychology)

Keywords

  • Anterior insula cortex
  • Attention-Deficit/Hyperactivity Disorder
  • Go/no-go test
  • Superior frontal cortex

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

Cite this

Segregating sustained attention from response inhibition in ADHD : An fMRI study. / Hwang, Soonjo; Meffert, Harma; Parsley, Ian; Tyler, Patrick M.; Erway, Anna K.; Botkin, Mary L.; Pope, Kayla; Blair, R. J.R.

In: NeuroImage: Clinical, Vol. 21, 101677, 2019.

Research output: Contribution to journalArticle

Hwang, Soonjo ; Meffert, Harma ; Parsley, Ian ; Tyler, Patrick M. ; Erway, Anna K. ; Botkin, Mary L. ; Pope, Kayla ; Blair, R. J.R. / Segregating sustained attention from response inhibition in ADHD : An fMRI study. In: NeuroImage: Clinical. 2019 ; Vol. 21.
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