Secondary exposure risks to patients in an airborne isolation room: Implications for anteroom design

Ehsan S. Mousavi, Kevin R. Grosskopf

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Placing an Airborne Infectious Isolation Room (AIIR) into a negative pressure has proven to protect the hospital from fatal pathogens such as tuberculosis and other airborne diseases. However, this pressurization strategy could increase the risk of isolation patients acquiring secondary infections from contaminated air drawn in from adjacent spaces. As a result, an actual hospital was used to observe the transport of aerosol from a general patient room and nurse station to a nearby airborne infectious isolation room. Two experimental studies were designed to analyze the performance of a negative anteroom. Aerosols ≤3.0 μm (viruses and most airborne bacteria) were found to be capable of migrating out of a general patient room to the vicinity of the nurse station. Concentrations of aerosols within the anteroom and isolation room increased from ambient when injected at the nurse station, indicating the capability of aerosols to migrate into the isolation room upon negative pressurization. Subsequently, a series of CFD models, validated by the experiments, were developed to simulate a positively pressurized anteroom. An anteroom with a positive pressure was shown to effectively terminate cross-contamination between the corridor and the isolation room in both directions.

Original languageEnglish (US)
Pages (from-to)131-137
Number of pages7
JournalBuilding and Environment
Volume104
DOIs
StatePublished - Aug 1 2016

Fingerprint

Aerosols
social isolation
aerosol
Pressurization
nurse
tuberculosis
Pathogens
Viruses
Bacteria
virus
Computational fluid dynamics
Contamination
experimental study
pathogen
environmental pollution
bacterium
contagious disease
risk exposure
air
Air

Keywords

  • Airborne
  • Anteroom
  • Hospital
  • Isolation
  • Secondary transmission
  • Ventilation

ASJC Scopus subject areas

  • Environmental Engineering
  • Civil and Structural Engineering
  • Geography, Planning and Development
  • Building and Construction

Cite this

Secondary exposure risks to patients in an airborne isolation room : Implications for anteroom design. / Mousavi, Ehsan S.; Grosskopf, Kevin R.

In: Building and Environment, Vol. 104, 01.08.2016, p. 131-137.

Research output: Contribution to journalArticle

@article{46ff889ccc5a476985b232b55ceea937,
title = "Secondary exposure risks to patients in an airborne isolation room: Implications for anteroom design",
abstract = "Placing an Airborne Infectious Isolation Room (AIIR) into a negative pressure has proven to protect the hospital from fatal pathogens such as tuberculosis and other airborne diseases. However, this pressurization strategy could increase the risk of isolation patients acquiring secondary infections from contaminated air drawn in from adjacent spaces. As a result, an actual hospital was used to observe the transport of aerosol from a general patient room and nurse station to a nearby airborne infectious isolation room. Two experimental studies were designed to analyze the performance of a negative anteroom. Aerosols ≤3.0 μm (viruses and most airborne bacteria) were found to be capable of migrating out of a general patient room to the vicinity of the nurse station. Concentrations of aerosols within the anteroom and isolation room increased from ambient when injected at the nurse station, indicating the capability of aerosols to migrate into the isolation room upon negative pressurization. Subsequently, a series of CFD models, validated by the experiments, were developed to simulate a positively pressurized anteroom. An anteroom with a positive pressure was shown to effectively terminate cross-contamination between the corridor and the isolation room in both directions.",
keywords = "Airborne, Anteroom, Hospital, Isolation, Secondary transmission, Ventilation",
author = "Mousavi, {Ehsan S.} and Grosskopf, {Kevin R.}",
year = "2016",
month = "8",
day = "1",
doi = "10.1016/j.buildenv.2016.05.010",
language = "English (US)",
volume = "104",
pages = "131--137",
journal = "Building and Environment",
issn = "0360-1323",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Secondary exposure risks to patients in an airborne isolation room

T2 - Implications for anteroom design

AU - Mousavi, Ehsan S.

AU - Grosskopf, Kevin R.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Placing an Airborne Infectious Isolation Room (AIIR) into a negative pressure has proven to protect the hospital from fatal pathogens such as tuberculosis and other airborne diseases. However, this pressurization strategy could increase the risk of isolation patients acquiring secondary infections from contaminated air drawn in from adjacent spaces. As a result, an actual hospital was used to observe the transport of aerosol from a general patient room and nurse station to a nearby airborne infectious isolation room. Two experimental studies were designed to analyze the performance of a negative anteroom. Aerosols ≤3.0 μm (viruses and most airborne bacteria) were found to be capable of migrating out of a general patient room to the vicinity of the nurse station. Concentrations of aerosols within the anteroom and isolation room increased from ambient when injected at the nurse station, indicating the capability of aerosols to migrate into the isolation room upon negative pressurization. Subsequently, a series of CFD models, validated by the experiments, were developed to simulate a positively pressurized anteroom. An anteroom with a positive pressure was shown to effectively terminate cross-contamination between the corridor and the isolation room in both directions.

AB - Placing an Airborne Infectious Isolation Room (AIIR) into a negative pressure has proven to protect the hospital from fatal pathogens such as tuberculosis and other airborne diseases. However, this pressurization strategy could increase the risk of isolation patients acquiring secondary infections from contaminated air drawn in from adjacent spaces. As a result, an actual hospital was used to observe the transport of aerosol from a general patient room and nurse station to a nearby airborne infectious isolation room. Two experimental studies were designed to analyze the performance of a negative anteroom. Aerosols ≤3.0 μm (viruses and most airborne bacteria) were found to be capable of migrating out of a general patient room to the vicinity of the nurse station. Concentrations of aerosols within the anteroom and isolation room increased from ambient when injected at the nurse station, indicating the capability of aerosols to migrate into the isolation room upon negative pressurization. Subsequently, a series of CFD models, validated by the experiments, were developed to simulate a positively pressurized anteroom. An anteroom with a positive pressure was shown to effectively terminate cross-contamination between the corridor and the isolation room in both directions.

KW - Airborne

KW - Anteroom

KW - Hospital

KW - Isolation

KW - Secondary transmission

KW - Ventilation

UR - http://www.scopus.com/inward/record.url?scp=84966703611&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966703611&partnerID=8YFLogxK

U2 - 10.1016/j.buildenv.2016.05.010

DO - 10.1016/j.buildenv.2016.05.010

M3 - Article

AN - SCOPUS:84966703611

VL - 104

SP - 131

EP - 137

JO - Building and Environment

JF - Building and Environment

SN - 0360-1323

ER -