Second Lymphoid Malignant Neoplasms Occurring in Patients Treated for Hodgkin's Disease

James Olen Armitage, Fred R. Dick, James A. Goeken, M. Kathy Foucar, Roger D. Gingrich

Research output: Contribution to journalArticle

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Abstract

Patients who have been treated for Hodgkin's disease are at increased risk for second malignant neoplasms, particularly acute nonlymphoblastic leukemia and non-Hodgkin's lymphold malignant neoplasms (NHLMs). We diagnosed five cases of NHLM in 242 patients initially treated for Hodgkin's disease between 1973 and 1980, giving a minimum incidence for this occurrence of 2.1%. The initial therapy for Hodgkin's disease, Irradiation in three patients and chemotherapy in two patients, resulted in a complete remission in each case. The NHLM appeared 12, 13, 26, 30, and 54 months after the diagnosis of Hodgkin's disease. The cell type of NHLM and immunologic phenotype were as follows: large cell, immunoblastic T; large cell, immunoblastic null; large cell, cleaved and noncleaved B; large cell, cleaved and noncleaved (not studied); and lymphoblastic T. A review of 24 other cases of NHLMs, occurring in patients treated for Hodgkin's disease, reported in the literature, confirm the morphologic and immunologic heterogeneity. The poor response to therapy in our patients and those previously described demonstrate the seriousness of this phenomenon.

Original languageEnglish (US)
Pages (from-to)445-450
Number of pages6
JournalArchives of Internal Medicine
Volume143
Issue number3
DOIs
StatePublished - Jan 1 1983

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Hodgkin Disease
Non-Hodgkin's Lymphoma
Neoplasms
Null Lymphocytes
Second Primary Neoplasms
Acute Myeloid Leukemia
Phenotype
Drug Therapy
Incidence
Therapeutics

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Second Lymphoid Malignant Neoplasms Occurring in Patients Treated for Hodgkin's Disease. / Armitage, James Olen; Dick, Fred R.; Goeken, James A.; Foucar, M. Kathy; Gingrich, Roger D.

In: Archives of Internal Medicine, Vol. 143, No. 3, 01.01.1983, p. 445-450.

Research output: Contribution to journalArticle

Armitage, James Olen ; Dick, Fred R. ; Goeken, James A. ; Foucar, M. Kathy ; Gingrich, Roger D. / Second Lymphoid Malignant Neoplasms Occurring in Patients Treated for Hodgkin's Disease. In: Archives of Internal Medicine. 1983 ; Vol. 143, No. 3. pp. 445-450.
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