Searching for the Endogenous Benzodiazepine Using the Graph Theoretical Approach

Rodney Smith Markin, W. J. Murray

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The graph theoretical indices of several compounds with reported benzodiazepine receptor binding affinities were calculated. Our results demonstrate a structural similarity among diazepam, triazolam, and the β-carboline nucleus and a structural dissimilarity to the purines and nicotinamide. This result correlates with their respective binding affinities. Using the graph theoretical indices as structural descriptors of the benzodiazepines and the significant ligands of the β-carbolines, a search for peptide sequences as potential ligands was explored. Single amino acids through pentapeptides with all possible amino acid substitutions and chemical modifications were calculated. The peptides generated were subjected to graph theoretical analysis, and their indices were compared to those of the benzodiazepines. Comparisons resulted in seven dipeptides and six tripeptides that are topologically similar to the benzodiazepines and β-carbolines. The dipeptides are histidine- or tryptophan-containing compounds with pyroglutamine, phenylalanine, and tyrosine residues in the second position. The tripeptides have two aromatic amino acid residues and a pyroglutamine or glycyl terminal residue. These structures are promising candidates because (1) they are structurally (topologically) similar to the benzodiazepines, represented by diazepam and triazolam, and to the β-carbolines; and (2) they are sequences that may reasonably form a part of a larger peptide or that may be formed metabolically by proteolysis.

Original languageEnglish (US)
Pages (from-to)408-412
Number of pages5
JournalPharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists
Volume5
Issue number7
DOIs
StatePublished - Jul 1988

Fingerprint

Carbolines
Benzodiazepines
Triazolam
Dipeptides
Diazepam
Peptides
Proteolysis
Ligands
Amino Acids
Aromatic Amino Acids
Purines
Niacinamide
Chemical modification
GABA-A Receptors
Amino Acid Substitution
Phenylalanine
Histidine
Tryptophan
Tyrosine
Substitution reactions

Keywords

  • QSAR, similarity
  • endogenous benzodiazepine
  • topological approach

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)

Cite this

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