Searching for electrical properties, phenomena and mechanisms in the construction and function of chromosomes

Ivan Kanev, Wai Ning Mei, Akira Mizuno, Kristi Dehaai, Jennifer N Sanmann, Michelle Hess, Lois J Starr, Jennifer Grove, Bhavana J Dave, Warren Sanger

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Our studies reveal previously unidentified electrical properties of chromosomes: (1) chromosomes are amazingly similar in construction and function to electrical transformers; (2) chromosomes possess in their construction and function, components similar to those of electric generators, conductors, condensers, switches, and other components of electrical circuits; (3) chromosomes demonstrate in nano-scale level electromagnetic interactions, resonance, fusion and other phenomena similar to those described by equations in classical physics. These electrical properties and phenomena provide a possible explanation for unclear and poorly understood mechanisms in clinical genetics including: (a) electrically based mechanisms responsible for breaks, translocations, fusions, and other chromosomal abnormalities associated with cancer, intellectual disability, infertility, pregnancy loss, Down syndrome, and other genetic disorders; (b) electrically based mechanisms involved in crossing over, non-disjunction and other events during meiosis and mitosis; (c) mechanisms demonstrating heterochromatin to be electrically active and genetically important.

Original languageEnglish (US)
Article numbera10
Pages (from-to)e201303007
JournalComputational and Structural Biotechnology Journal
Volume6
Issue number7
DOIs
StatePublished - Jan 1 2013

Fingerprint

Electromagnetic Phenomena
Chromosomes
Electric properties
Inborn Genetic Diseases
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 2
Heterochromatin
Chromosomes, Human, Pair 1
Physics
Meiosis
Down Syndrome
Mitosis
Chromosome Aberrations
Intellectual Disability
Infertility
Fusion reactions
Electric generators
Pregnancy
Neoplasms
Switches

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Structural Biology
  • Biochemistry
  • Genetics
  • Computer Science Applications

Cite this

Searching for electrical properties, phenomena and mechanisms in the construction and function of chromosomes. / Kanev, Ivan; Mei, Wai Ning; Mizuno, Akira; Dehaai, Kristi; Sanmann, Jennifer N; Hess, Michelle; Starr, Lois J; Grove, Jennifer; Dave, Bhavana J; Sanger, Warren.

In: Computational and Structural Biotechnology Journal, Vol. 6, No. 7, a10, 01.01.2013, p. e201303007.

Research output: Contribution to journalArticle

Kanev, Ivan ; Mei, Wai Ning ; Mizuno, Akira ; Dehaai, Kristi ; Sanmann, Jennifer N ; Hess, Michelle ; Starr, Lois J ; Grove, Jennifer ; Dave, Bhavana J ; Sanger, Warren. / Searching for electrical properties, phenomena and mechanisms in the construction and function of chromosomes. In: Computational and Structural Biotechnology Journal. 2013 ; Vol. 6, No. 7. pp. e201303007.
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