Abstract

Nutritional status is a well-recognized prognostic indicator in chronic obstructive pulmonary disease (COPD); however, very little is known about the relationship between lung function and saturated fat intake. We used data from the cross-sectional National Health and Nutrition Examination Surveys (NHANES) to assess the relationship between saturated fatty acid (SFA) intake and lung function in the general US adult population. Adults in NHANES (2007–2012) with pre-bronchodilator spirometry measurements and dietary SFA intake were included. Primary outcomes were lung function including forced expiratory volume in one second (FEV 1 ), FEV 1 , forced vital capacity (FVC), FEV 1 /FVC ratio, percent predicted FEV 1 and percent predicted FVCMultivariable regression models in the general population as well as those with spirometry-defined airflow obstruction were used to assess the relationship between lung function measurements and dietary SFA intake after adjustment for confounders. 11,180 eligible participants were included in this study. Univariate analysis revealed a statistically significant positive association between total SFA intake and lung function outcomes; however, these relationships were attenuated after adjustment for covariates. A secondary analysis of individuals with spirometry-defined airflow obstruction (FEV 1 /FVC < 0.7) revealed that a lower intake of SFA was associated with reduced FEV 1 (β = −126.4, p = 0.04 for quartile 1 vs. quartile 4), FVC (β = −165.8. p = 0.01 for quartile 1 vs. quartile 4), and percent predicted FVC (β = −3.3. p = 0.04 for quartile 1 vs. quartile 4), after adjustment for relevant confounders. No associations were observed for the FEV 1 /FVC ratio and percent predicted FEV 1 . It is possible that characteristics such as food source and fatty acid chain length may influence associations between saturated fatty acid intake and health outcomes.

Original languageEnglish (US)
Article number317
JournalNutrients
Volume11
Issue number2
DOIs
StatePublished - Jan 1 2019

Fingerprint

National Health and Nutrition Examination Survey
Nutrition Surveys
lung function
fat intake
air flow
Vital Capacity
saturated fatty acids
Fatty Acids
Fats
Lung
Spirometry
bronchodilators
Bronchodilator Agents
Forced Expiratory Volume
respiratory tract diseases
nutritional status
saturated fats
Nutritional Status
Chronic Obstructive Pulmonary Disease
Population

Keywords

  • COPD
  • Lipids
  • Lung function
  • NHANES
  • Saturated fat

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Saturated fat intake is associated with lung function in individuals with airflow obstruction : Results from NHANES 2007–2012. / Cornell, Kasey; Alam, Morshed; Lyden, Elizabeth; Wood, Lisa; Levan, Tricia D.; Nordgren, Tara M.; Bailey, Kristina; Hanson, Corrine.

In: Nutrients, Vol. 11, No. 2, 317, 01.01.2019.

Research output: Contribution to journalArticle

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abstract = "Nutritional status is a well-recognized prognostic indicator in chronic obstructive pulmonary disease (COPD); however, very little is known about the relationship between lung function and saturated fat intake. We used data from the cross-sectional National Health and Nutrition Examination Surveys (NHANES) to assess the relationship between saturated fatty acid (SFA) intake and lung function in the general US adult population. Adults in NHANES (2007–2012) with pre-bronchodilator spirometry measurements and dietary SFA intake were included. Primary outcomes were lung function including forced expiratory volume in one second (FEV 1 ), FEV 1 , forced vital capacity (FVC), FEV 1 /FVC ratio, percent predicted FEV 1 and percent predicted FVCMultivariable regression models in the general population as well as those with spirometry-defined airflow obstruction were used to assess the relationship between lung function measurements and dietary SFA intake after adjustment for confounders. 11,180 eligible participants were included in this study. Univariate analysis revealed a statistically significant positive association between total SFA intake and lung function outcomes; however, these relationships were attenuated after adjustment for covariates. A secondary analysis of individuals with spirometry-defined airflow obstruction (FEV 1 /FVC < 0.7) revealed that a lower intake of SFA was associated with reduced FEV 1 (β = −126.4, p = 0.04 for quartile 1 vs. quartile 4), FVC (β = −165.8. p = 0.01 for quartile 1 vs. quartile 4), and percent predicted FVC (β = −3.3. p = 0.04 for quartile 1 vs. quartile 4), after adjustment for relevant confounders. No associations were observed for the FEV 1 /FVC ratio and percent predicted FEV 1 . It is possible that characteristics such as food source and fatty acid chain length may influence associations between saturated fatty acid intake and health outcomes.",
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AU - Cornell, Kasey

AU - Alam, Morshed

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