Abstract
Nutritional status is a well-recognized prognostic indicator in chronic obstructive pulmonary disease (COPD); however, very little is known about the relationship between lung function and saturated fat intake. We used data from the cross-sectional National Health and Nutrition Examination Surveys (NHANES) to assess the relationship between saturated fatty acid (SFA) intake and lung function in the general US adult population. Adults in NHANES (2007–2012) with pre-bronchodilator spirometry measurements and dietary SFA intake were included. Primary outcomes were lung function including forced expiratory volume in one second (FEV 1 ), FEV 1 , forced vital capacity (FVC), FEV 1 /FVC ratio, percent predicted FEV 1 and percent predicted FVCMultivariable regression models in the general population as well as those with spirometry-defined airflow obstruction were used to assess the relationship between lung function measurements and dietary SFA intake after adjustment for confounders. 11,180 eligible participants were included in this study. Univariate analysis revealed a statistically significant positive association between total SFA intake and lung function outcomes; however, these relationships were attenuated after adjustment for covariates. A secondary analysis of individuals with spirometry-defined airflow obstruction (FEV 1 /FVC < 0.7) revealed that a lower intake of SFA was associated with reduced FEV 1 (β = −126.4, p = 0.04 for quartile 1 vs. quartile 4), FVC (β = −165.8. p = 0.01 for quartile 1 vs. quartile 4), and percent predicted FVC (β = −3.3. p = 0.04 for quartile 1 vs. quartile 4), after adjustment for relevant confounders. No associations were observed for the FEV 1 /FVC ratio and percent predicted FEV 1 . It is possible that characteristics such as food source and fatty acid chain length may influence associations between saturated fatty acid intake and health outcomes.
| Original language | English (US) |
|---|---|
| Article number | 317 |
| Journal | Nutrients |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- COPD
- Lipids
- Lung function
- NHANES
- Saturated fat
ASJC Scopus subject areas
- Food Science
- Nutrition and Dietetics
Cite this
Saturated fat intake is associated with lung function in individuals with airflow obstruction : Results from NHANES 2007–2012. / Cornell, Kasey; Alam, Morshed; Lyden, Elizabeth; Wood, Lisa; Levan, Tricia D.; Nordgren, Tara M.; Bailey, Kristina; Hanson, Corrine.
In: Nutrients, Vol. 11, No. 2, 317, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Saturated fat intake is associated with lung function in individuals with airflow obstruction
T2 - Results from NHANES 2007–2012
AU - Cornell, Kasey
AU - Alam, Morshed
AU - Lyden, Elizabeth
AU - Wood, Lisa
AU - Levan, Tricia D.
AU - Nordgren, Tara M.
AU - Bailey, Kristina
AU - Hanson, Corrine
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Nutritional status is a well-recognized prognostic indicator in chronic obstructive pulmonary disease (COPD); however, very little is known about the relationship between lung function and saturated fat intake. We used data from the cross-sectional National Health and Nutrition Examination Surveys (NHANES) to assess the relationship between saturated fatty acid (SFA) intake and lung function in the general US adult population. Adults in NHANES (2007–2012) with pre-bronchodilator spirometry measurements and dietary SFA intake were included. Primary outcomes were lung function including forced expiratory volume in one second (FEV 1 ), FEV 1 , forced vital capacity (FVC), FEV 1 /FVC ratio, percent predicted FEV 1 and percent predicted FVCMultivariable regression models in the general population as well as those with spirometry-defined airflow obstruction were used to assess the relationship between lung function measurements and dietary SFA intake after adjustment for confounders. 11,180 eligible participants were included in this study. Univariate analysis revealed a statistically significant positive association between total SFA intake and lung function outcomes; however, these relationships were attenuated after adjustment for covariates. A secondary analysis of individuals with spirometry-defined airflow obstruction (FEV 1 /FVC < 0.7) revealed that a lower intake of SFA was associated with reduced FEV 1 (β = −126.4, p = 0.04 for quartile 1 vs. quartile 4), FVC (β = −165.8. p = 0.01 for quartile 1 vs. quartile 4), and percent predicted FVC (β = −3.3. p = 0.04 for quartile 1 vs. quartile 4), after adjustment for relevant confounders. No associations were observed for the FEV 1 /FVC ratio and percent predicted FEV 1 . It is possible that characteristics such as food source and fatty acid chain length may influence associations between saturated fatty acid intake and health outcomes.
AB - Nutritional status is a well-recognized prognostic indicator in chronic obstructive pulmonary disease (COPD); however, very little is known about the relationship between lung function and saturated fat intake. We used data from the cross-sectional National Health and Nutrition Examination Surveys (NHANES) to assess the relationship between saturated fatty acid (SFA) intake and lung function in the general US adult population. Adults in NHANES (2007–2012) with pre-bronchodilator spirometry measurements and dietary SFA intake were included. Primary outcomes were lung function including forced expiratory volume in one second (FEV 1 ), FEV 1 , forced vital capacity (FVC), FEV 1 /FVC ratio, percent predicted FEV 1 and percent predicted FVCMultivariable regression models in the general population as well as those with spirometry-defined airflow obstruction were used to assess the relationship between lung function measurements and dietary SFA intake after adjustment for confounders. 11,180 eligible participants were included in this study. Univariate analysis revealed a statistically significant positive association between total SFA intake and lung function outcomes; however, these relationships were attenuated after adjustment for covariates. A secondary analysis of individuals with spirometry-defined airflow obstruction (FEV 1 /FVC < 0.7) revealed that a lower intake of SFA was associated with reduced FEV 1 (β = −126.4, p = 0.04 for quartile 1 vs. quartile 4), FVC (β = −165.8. p = 0.01 for quartile 1 vs. quartile 4), and percent predicted FVC (β = −3.3. p = 0.04 for quartile 1 vs. quartile 4), after adjustment for relevant confounders. No associations were observed for the FEV 1 /FVC ratio and percent predicted FEV 1 . It is possible that characteristics such as food source and fatty acid chain length may influence associations between saturated fatty acid intake and health outcomes.
KW - COPD
KW - Lipids
KW - Lung function
KW - NHANES
KW - Saturated fat
UR - http://www.scopus.com/inward/record.url?scp=85061111435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061111435&partnerID=8YFLogxK
U2 - 10.3390/nu11020317
DO - 10.3390/nu11020317
M3 - Article
C2 - 30717299
AN - SCOPUS:85061111435
VL - 11
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 2
M1 - 317
ER -