Sandwich-type fiber scaffolds with square arrayed microwells and nanostructured cues as microskin grafts for skin regeneration

Bing Ma, Jingwei Xie, Jiang Jiang, Jun Wu

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The paper reports the fabrication of sandwich-type scaffolds consisting of radially-aligned nanofibers at the bottom, nanofiber membranes with square arrayed microwells and nanostructured cues at the top, and microskin tissues in between as microskin grafts for use in skin regeneration. This class of nanofiber scaffolds was able to confine the microskin tissues in the square arrayed wells and simultaneously present nanotopographic cues to the cultured NIH 3T3 fibroblasts and primary rat skin cells, guiding and facilitating their migration invitro. More importantly, we demonstrated that the sandwich-type transplants exhibited an even distribution of microskin grafts, greatly improved the 'take' rate of microskin tissues, and promoted re-epithelialization on wound invivo. In addition, the void area in the scaffolds was well suitable for exudate drainage in wound. The sandwich-type scaffolds show great potential as microskin grafts for repairing extensive burn injuries and may provide a good solution for the treatment of acute skin defects and chronic wounds including diabetic ulcer, pressure ulcer, and venous stasis ulcer.

Original languageEnglish (US)
Pages (from-to)630-641
Number of pages12
JournalBiomaterials
Volume35
Issue number2
DOIs
StatePublished - Jan 1 2014

Fingerprint

Nanofibers
Grafts
Scaffolds
Cues
Regeneration
Skin
Tissue
Transplants
Fibers
Wounds and Injuries
Fibroblasts
Scaffolds (biology)
Re-Epithelialization
Varicose Ulcer
Drainage
Rats
Pressure Ulcer
Exudates and Transudates
Ulcer
Membranes

Keywords

  • Arrayed microwells
  • Nanofiber scaffolds
  • Nanotopographic cue
  • Sandwich-type
  • Skin regeneration

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Sandwich-type fiber scaffolds with square arrayed microwells and nanostructured cues as microskin grafts for skin regeneration. / Ma, Bing; Xie, Jingwei; Jiang, Jiang; Wu, Jun.

In: Biomaterials, Vol. 35, No. 2, 01.01.2014, p. 630-641.

Research output: Contribution to journalArticle

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