Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children

Anu Nurkka, Jenny MacLennan, Virva Jäntti, Steven Obaro, Brian Greenwood, Helena Käyhty

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Development of salivary antibodies at the age of 4 or 5 years to group A and C meningococcal polysaccharides (MenA/C PS) was studied among Gambian children, who had received MenA/C conjugate or PS vaccine in infancy. There was also a control group of 64 age matched children. IgG, IgA, and secretory Ig concentrations were measured by enzyme immuno assay. MenA/C PS vaccine induced antibodies both in previously vaccinated and unvaccinated children. The previous vaccination had not induced long lasting IgA-mediated memory. IgA antibodies were secretory, and most of IgG was serum derived. The IgG salivary response seen was similar to the serum response. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)547-556
Number of pages10
JournalVaccine
Volume19
Issue number4-5
DOIs
StatePublished - Oct 15 2000

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Keywords

  • Meningococcal vaccines
  • Salivary antibodies

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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