Long term treatment with high doses of sodium saccharin in the diet beginning in utero or at birth induces urinary bladder tumours in the rat with a higher incidence in male rats compared to female rats. After one of the most extensive toxicological evaluations of any chemical, it ultimately was shown that saccharin-induced bladder cancer in rats is a species-specific high dose phenomenon, and It is now accepted that saccharin does not pose a cancer risk to humans. The methodology utilized and the issues investigated in the research with saccharin have greatly extended the sciences of toxicology, epidemiology and risk assessment for chemicals.
|Original language||English (US)|
|Number of pages||5|
|Journal||Agro Food Industry Hi-Tech|
|State||Published - Nov 1 2008|
ASJC Scopus subject areas
- Food Science
- Industrial and Manufacturing Engineering