Safety and performance benefits of arginine supplements for military personnel

A systematic review

James R. Brooks, Hellen Oketch-Rabah, Tieraona Low Dog, Dennis K.J. Gorecki, Marilyn L. Barrett, Louis Cantilena, Mei Chung, Rebecca B. Costello, Johanna Dwyer, Mary L. Hardy, Scott A. Jordan, Ronald J. Maughan, Robin J. Marles, Robert E. Osterberg, Bruce E. Rodda, Robert R. Wolfe, Jorge M Zuniga, Luis G. Valerio, Donnamaria Jones, Patricia Deuster & 2 others Gabriel I. Giancaspro, Nandakumara D. Sarma

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Context: Dietary supplements are widely used by military personnel and civilians for promotion of health. Objective: The objective of this evidence-based review was to examine whether supplementation with L-arginine, in combination with caffeine and/or creatine, is safe and whether it enhances athletic performance or improves recovery from exhaustion for military personnel. Data Sources: Information from clinical trials and adverse event reports were collected from 17 databases and 5 adverse event report portals. Study Selection: Studies and reports were included if they evaluated the safety and the putative outcomes of enhanced performance or improved recovery from exhaustion associated with the intake of arginine alone or in combination with caffeine and/or creatine in healthy adults aged 19 to 50 years. Data Extraction: Information related to population, intervention, comparator, and outcomes was abstracted. Of the 2687 articles screened, 62 articles meeting the inclusion criteria were analyzed. Strength of evidence was assessed in terms of risk of bias, consistency, directness, and precision. Results: Most studies had few participants and suggested risk of bias that could negatively affect the results. L-Arginine supplementation provided little enhancement of athletic performance or improvements in recovery. Short-term supplementation with arginine may result in adverse gastrointestinal and cardiovascular effects. No information about the effects of arginine on the performance of military personnel was available. Conclusions: The available information does not support the use of L-arginine, either alone or in combination with caffeine, creatine, or both, to enhance athletic performance or improve recovery from exhaustion. Given the information gaps, an evidence-based review to assess the safety or effectiveness of multi-ingredient dietary supplements was not feasible, and therefore the development of a computational model-based approach to predict the safety of multi-ingredient dietary supplements is recommended.

Original languageEnglish (US)
Pages (from-to)708-721
Number of pages14
JournalNutrition Reviews
Volume74
Issue number11
DOIs
StatePublished - Nov 1 2016

Fingerprint

Military Personnel
Arginine
Safety
Athletic Performance
Creatine
Dietary Supplements
Caffeine
Information Storage and Retrieval
Health Promotion
Clinical Trials
Databases
Population

Keywords

  • Arginine
  • Caffeine
  • Creatine
  • Dietary supplements
  • Performance enhancement

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Brooks, J. R., Oketch-Rabah, H., Dog, T. L., Gorecki, D. K. J., Barrett, M. L., Cantilena, L., ... Sarma, N. D. (2016). Safety and performance benefits of arginine supplements for military personnel: A systematic review. Nutrition Reviews, 74(11), 708-721. https://doi.org/10.1093/nutrit/nuw040

Safety and performance benefits of arginine supplements for military personnel : A systematic review. / Brooks, James R.; Oketch-Rabah, Hellen; Dog, Tieraona Low; Gorecki, Dennis K.J.; Barrett, Marilyn L.; Cantilena, Louis; Chung, Mei; Costello, Rebecca B.; Dwyer, Johanna; Hardy, Mary L.; Jordan, Scott A.; Maughan, Ronald J.; Marles, Robin J.; Osterberg, Robert E.; Rodda, Bruce E.; Wolfe, Robert R.; Zuniga, Jorge M; Valerio, Luis G.; Jones, Donnamaria; Deuster, Patricia; Giancaspro, Gabriel I.; Sarma, Nandakumara D.

In: Nutrition Reviews, Vol. 74, No. 11, 01.11.2016, p. 708-721.

Research output: Contribution to journalArticle

Brooks, JR, Oketch-Rabah, H, Dog, TL, Gorecki, DKJ, Barrett, ML, Cantilena, L, Chung, M, Costello, RB, Dwyer, J, Hardy, ML, Jordan, SA, Maughan, RJ, Marles, RJ, Osterberg, RE, Rodda, BE, Wolfe, RR, Zuniga, JM, Valerio, LG, Jones, D, Deuster, P, Giancaspro, GI & Sarma, ND 2016, 'Safety and performance benefits of arginine supplements for military personnel: A systematic review', Nutrition Reviews, vol. 74, no. 11, pp. 708-721. https://doi.org/10.1093/nutrit/nuw040
Brooks JR, Oketch-Rabah H, Dog TL, Gorecki DKJ, Barrett ML, Cantilena L et al. Safety and performance benefits of arginine supplements for military personnel: A systematic review. Nutrition Reviews. 2016 Nov 1;74(11):708-721. https://doi.org/10.1093/nutrit/nuw040
Brooks, James R. ; Oketch-Rabah, Hellen ; Dog, Tieraona Low ; Gorecki, Dennis K.J. ; Barrett, Marilyn L. ; Cantilena, Louis ; Chung, Mei ; Costello, Rebecca B. ; Dwyer, Johanna ; Hardy, Mary L. ; Jordan, Scott A. ; Maughan, Ronald J. ; Marles, Robin J. ; Osterberg, Robert E. ; Rodda, Bruce E. ; Wolfe, Robert R. ; Zuniga, Jorge M ; Valerio, Luis G. ; Jones, Donnamaria ; Deuster, Patricia ; Giancaspro, Gabriel I. ; Sarma, Nandakumara D. / Safety and performance benefits of arginine supplements for military personnel : A systematic review. In: Nutrition Reviews. 2016 ; Vol. 74, No. 11. pp. 708-721.
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