Saccharin-Induced Hyperplasia of the Rat Urinary Bladder

Shoji Fukushima, Samuel M. Cohen

Research output: Contribution to journalArticle

103 Scopus citations

Abstract

Dietary administration of sodium saccharin to male Fischer rats increased the rate of DNA synthesis of the urinary bladder epithelium as measured by tritiated thymidine uptake. A multifocal mild epithelial hyperplasia was induced, which was most readily detected by scanning electron microscopy, with pleomorphic microvilli present on many of the hyperplastic cells.

Original languageEnglish (US)
Pages (from-to)734-736
Number of pages3
JournalCancer Research
Volume40
Issue number3
StatePublished - Mar 1 1980

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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