Saccharin-Induced Hyperplasia of the Rat Urinary Bladder

Shoji Fukushima, Samuel M. Cohen

Research output: Contribution to journalArticle

103 Scopus citations


Dietary administration of sodium saccharin to male Fischer rats increased the rate of DNA synthesis of the urinary bladder epithelium as measured by tritiated thymidine uptake. A multifocal mild epithelial hyperplasia was induced, which was most readily detected by scanning electron microscopy, with pleomorphic microvilli present on many of the hyperplastic cells.

Original languageEnglish (US)
Pages (from-to)734-736
Number of pages3
JournalCancer Research
Issue number3
StatePublished - Mar 1 1980


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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