Ruxolitinib: A steroid sparing agent in chronic graft-versus-host disease

Hanna Jean Khoury, Amelia A. Langston, Vamsi K. Kota, Jennifer A. Wilkinson, Iskra Pusic, Anand Jillella, Stephanie Bauer, Audrey S. Kim, Danielle Roberts, Zaid Al-Kadhimi, Imre Bodo, Elliott Winton, Martha Arellano, John F. Dipersio

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24 Scopus citations

Abstract

Inhibition of the Janus-associated kinases (JAK) with ruxolitinib (RUX) reduces graft-versus-host disease (GVHD) in preclinical and clinical models. In total 19 allograft recipients with moderate/severe steroid-dependent chronic GVHD received RUX as ≥2nd line salvage. RUX was well tolerated, and led to complete/partial resolution of oral (92/7%), cutaneous (82/0%), hepatic (71/28%), gastro-intestinal (75/17%), musculoskeletal (33/67%), pulmonary (0/80%), scleroderma (0/75%), vaginal (0/75%), and ocular (0/100%) chronic GVHD. Overall 18 achieved partial response and 1 complete response according to NIH Consensus Criteria. Responses occurred early and were sustained which enabled discontinuation (68%) or reduction of steroids to physiologic doses (21%). We conclude that RUX is an effective steroid-sparing agent in chronic GVHD.

Original languageEnglish (US)
Pages (from-to)826-831
Number of pages6
JournalBone marrow transplantation
Volume53
Issue number7
DOIs
StatePublished - Jul 1 2018

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ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Khoury, H. J., Langston, A. A., Kota, V. K., Wilkinson, J. A., Pusic, I., Jillella, A., Bauer, S., Kim, A. S., Roberts, D., Al-Kadhimi, Z., Bodo, I., Winton, E., Arellano, M., & Dipersio, J. F. (2018). Ruxolitinib: A steroid sparing agent in chronic graft-versus-host disease. Bone marrow transplantation, 53(7), 826-831. https://doi.org/10.1038/s41409-017-0081-5