RUNX1 repression-independent mechanisms of leukemogenesis by fusion genes CBFB-MYH11 and AML1-ETO (RUNX1-RUNX1T1)

R. Katherine Hyde, P. Paul Liu

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

The core binding factor (CBF) acute myeloid leukemias (AMLs) are a prognostically distinct subgroup that includes patients with the inv(16) and t(8:21) chromosomal rearrangements. Both of these rearrangements result in the formation of fusion proteins, CBFB-MYH11 and AML1-ETO, respectively, that involve members of the CBF family of transcription factors. It has been proposed that both of these fusion proteins function primarily by dominantly repressing normal CBF transcription. However, recent reports have indicted that additional, CBF-repression independent activities may be equally important during leukemogenesis. This article will focus on these recent advances.

Original languageEnglish (US)
Pages (from-to)1039-1045
Number of pages7
JournalJournal of Cellular Biochemistry
Volume110
Issue number5
DOIs
Publication statusPublished - Aug 1 2010

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Keywords

  • AML
  • AML1-ETO
  • CBFB
  • CBFB-MYH11
  • RUNX1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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