RUNX1 and CBFβ mutations and activities of their wild-type alleles in AML

Ricia K Hyde, Paul Liu, Alan D. Friedman

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Mutations in RUNX1 and CBFB have long been recognized as important in hematological malignancies. Point mutations and deletions of RUNX1 are frequently found in myelodysplastic syndrome, myeloproliferative disease, and acute myeloid leukemia. Germline mutations in RUNX1 are associated with familial platelet disorder with predisposition to AML. In addition, as will be discussed in other chapters, both RUNX1 and CBFB are involved in recurrent chromosomal rearrangements in leukemia. More recently, roles for the non-mutated RUNX1 and CBFB genes have been identified in multiple leukemia subtypes. This chapter will discuss the roles of RUNX1 and CBFB, both in diseases caused by their mutations or deletions, as well as in the context of chromosomal rearrangements.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages265-282
Number of pages18
Volume962
DOIs
StatePublished - 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume962
ISSN (Print)00652598
ISSN (Electronic)22148019

Fingerprint

Myelodysplastic-Myeloproliferative Diseases
Leukemia
Alleles
Mutation
Germ-Line Mutation
Sequence Deletion
Myelodysplastic Syndromes
Hematologic Neoplasms
Platelets
Point Mutation
Acute Myeloid Leukemia
Blood Platelets
Genes

Keywords

  • AML
  • CBFB
  • Inv(16)
  • MDS
  • MLL
  • MPD
  • RUNX1
  • t(8;21)

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hyde, R. K., Liu, P., & Friedman, A. D. (2017). RUNX1 and CBFβ mutations and activities of their wild-type alleles in AML. In Advances in Experimental Medicine and Biology (Vol. 962, pp. 265-282). (Advances in Experimental Medicine and Biology; Vol. 962). Springer New York LLC. https://doi.org/10.1007/978-981-10-3233-2_17

RUNX1 and CBFβ mutations and activities of their wild-type alleles in AML. / Hyde, Ricia K; Liu, Paul; Friedman, Alan D.

Advances in Experimental Medicine and Biology. Vol. 962 Springer New York LLC, 2017. p. 265-282 (Advances in Experimental Medicine and Biology; Vol. 962).

Research output: Chapter in Book/Report/Conference proceedingChapter

Hyde, RK, Liu, P & Friedman, AD 2017, RUNX1 and CBFβ mutations and activities of their wild-type alleles in AML. in Advances in Experimental Medicine and Biology. vol. 962, Advances in Experimental Medicine and Biology, vol. 962, Springer New York LLC, pp. 265-282. https://doi.org/10.1007/978-981-10-3233-2_17
Hyde RK, Liu P, Friedman AD. RUNX1 and CBFβ mutations and activities of their wild-type alleles in AML. In Advances in Experimental Medicine and Biology. Vol. 962. Springer New York LLC. 2017. p. 265-282. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-981-10-3233-2_17
Hyde, Ricia K ; Liu, Paul ; Friedman, Alan D. / RUNX1 and CBFβ mutations and activities of their wild-type alleles in AML. Advances in Experimental Medicine and Biology. Vol. 962 Springer New York LLC, 2017. pp. 265-282 (Advances in Experimental Medicine and Biology).
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