Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis

Jun Ting Fan, Yi Shan Chen, Wen Yan Xu, Liangcheng Du, Guang Zhi Zeng, Yu Mei Zhang, Jia Su, Yan Li, Ning Hua Tan

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Two novel cyclic hexapeptides, named rubiyunnanins A (1) and B (2), were isolated from the roots of Rubia yunnanensis (Franch.) Diels. Their structures were elucidated extensively by spectroscopic analysis and theoretical computation. Possible biosynthetic pathways for RAs, 1, and 2 were proposed. Compound 2 showed moderate cytotoxicities against 11 cancer cell lines and inhibited nitric oxide (NO) production in LPS and IFN-γ-induced RAW 264.7 murine macrophages.

Original languageEnglish (US)
Pages (from-to)6810-6813
Number of pages4
JournalTetrahedron Letters
Volume51
Issue number52
DOIs
StatePublished - Dec 29 2010

Fingerprint

Rubia
Spectroscopic analysis
Macrophages
Biosynthetic Pathways
Cytotoxicity
Nitric Oxide
Cells
Cell Line
Neoplasms

Keywords

  • Cyclopeptides
  • Cytotoxicity
  • Inhibition of NO production
  • Rubia yunnanensis
  • Rubiyunnanin A
  • Rubiyunnanin B

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Fan, J. T., Chen, Y. S., Xu, W. Y., Du, L., Zeng, G. Z., Zhang, Y. M., ... Tan, N. H. (2010). Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis. Tetrahedron Letters, 51(52), 6810-6813. https://doi.org/10.1016/j.tetlet.2010.07.066

Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis. / Fan, Jun Ting; Chen, Yi Shan; Xu, Wen Yan; Du, Liangcheng; Zeng, Guang Zhi; Zhang, Yu Mei; Su, Jia; Li, Yan; Tan, Ning Hua.

In: Tetrahedron Letters, Vol. 51, No. 52, 29.12.2010, p. 6810-6813.

Research output: Contribution to journalArticle

Fan, JT, Chen, YS, Xu, WY, Du, L, Zeng, GZ, Zhang, YM, Su, J, Li, Y & Tan, NH 2010, 'Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis', Tetrahedron Letters, vol. 51, no. 52, pp. 6810-6813. https://doi.org/10.1016/j.tetlet.2010.07.066
Fan, Jun Ting ; Chen, Yi Shan ; Xu, Wen Yan ; Du, Liangcheng ; Zeng, Guang Zhi ; Zhang, Yu Mei ; Su, Jia ; Li, Yan ; Tan, Ning Hua. / Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis. In: Tetrahedron Letters. 2010 ; Vol. 51, No. 52. pp. 6810-6813.
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