Rotavirus gastroenteritis

Alexander K.C. Leung, James D. Kellner, Herbert Dele Davies

Research output: Contribution to journalReview article

48 Citations (Scopus)

Abstract

Rotavirus is the single most important cause of severe, dehydrating gastroenteritis in infants and young children worldwide. Rotavirus gastroenteritis is associated with high morbidity in developed countries and significant mortality in developing countries. Virtually all children are infected with rotavirus by 3 years of age. Fecal-oral transmission is the most likely route of virus spread. Group A serotype strains G1 through G4 account for more than 90% of rotavirus gastroenteritis in humans, with G1 being the predominant serotype. The virus preferentially infects the mature small-intestinal enterocytes. Rotavirus gastroenteritis is characterized by fever, vomiting, and diarrhea, with vomiting particularly prominent. Dehydration is a frequent complication because of the severity of the diarrhea and the associated vomiting. Rehydration and maintenance of proper fluid and electrolyte balance remain the mainstay of treatment. Hygienic measures have little effect on the reduction of rotavirus infection rates. The disease can be effectively controlled by universal rotavirus vaccination.

Original languageEnglish (US)
Pages (from-to)476-487
Number of pages12
JournalAdvances in Therapy
Volume22
Issue number5
DOIs
StatePublished - Jan 1 2005

Fingerprint

Rotavirus
Gastroenteritis
Vomiting
Water-Electrolyte Balance
Diarrhea
Viruses
Rotavirus Infections
Enterocytes
Fluid Therapy
Dehydration
Developed Countries
Developing Countries
Vaccination
Fever
Maintenance
Morbidity
Mortality

Keywords

  • Dehydration
  • Gastroenteritis
  • Morbidity
  • Mortality
  • Rotavirus
  • Vaccine

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Rotavirus gastroenteritis. / Leung, Alexander K.C.; Kellner, James D.; Davies, Herbert Dele.

In: Advances in Therapy, Vol. 22, No. 5, 01.01.2005, p. 476-487.

Research output: Contribution to journalReview article

Leung, AKC, Kellner, JD & Davies, HD 2005, 'Rotavirus gastroenteritis', Advances in Therapy, vol. 22, no. 5, pp. 476-487. https://doi.org/10.1007/BF02849868
Leung, Alexander K.C. ; Kellner, James D. ; Davies, Herbert Dele. / Rotavirus gastroenteritis. In: Advances in Therapy. 2005 ; Vol. 22, No. 5. pp. 476-487.
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