RON - the con in colorectal carcinoma

Shikha Tarang, Jing Wang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The recepteur d'origine nantais (RON) is a member of MET family of receptor tyrosine kinase (RTKs), an overexpression of which has been observed in several cancers. The expression of RON gene is required during embryonic development and also plays critical roles in regulating macrophage inflammatory response. In CRC, the overexpression of moderate RON activity contributes to their oncogenic potential by regulating several key processes such as proliferation, motility and resistance to apoptosis. Interestingly, an aberrant RON expression is often associated with the generation of several splice variants with unique transforming activities. The targeting of RON signaling pathway by the use of mono-clonal antibodies and small-molecule inhibitors has shown promising therapeutic results in animal models. The present ar-ticle aims at summarizing the current understanding of RON kinase in CRC.

Original languageEnglish (US)
Number of pages1
JournalOpen Colorectal Cancer Journal
Volume5
Issue number1
DOIs
StatePublished - May 14 2012

Fingerprint

Colorectal Neoplasms
Proto-Oncogene Proteins c-met
Embryonic Development
RON protein
Phosphotransferases
Animal Models
Macrophages
Apoptosis
Antibodies
Genes
Neoplasms
Therapeutics

Keywords

  • Colorectal cancer
  • Macrophage
  • Receptor Tyrosine kinase
  • Ron kinase
  • Splice Variants
  • Therapeutic Targeting

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

Cite this

RON - the con in colorectal carcinoma. / Tarang, Shikha; Wang, Jing.

In: Open Colorectal Cancer Journal, Vol. 5, No. 1, 14.05.2012.

Research output: Contribution to journalArticle

Tarang, Shikha ; Wang, Jing. / RON - the con in colorectal carcinoma. In: Open Colorectal Cancer Journal. 2012 ; Vol. 5, No. 1.
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