Roles of microRNAs in T cell immunity: Implications for strategy development against infectious diseases

Bikash R. Giri, Ram I Mahato, Guofeng Cheng

Research output: Contribution to journalReview article

Abstract

T cell immunity plays a vital role in pathogen infections. MicroRNA (miRNAs) are small, single-stranded noncoding RNAs that regulate T cell immunity by targeting key transcriptional factors, signaling proteins, and cytokines associated with T cell activation, differentiation, and function. The dysregulation of miRNA expression in T cells may lead to specific immune responses and can provide new therapeutic opportunities against various infectious diseases. Here, we summarize recent studies that focus on the roles of miRNAs in T cell immunity and highlight miRNA functions in prevalent infectious diseases. Additionally, we also provide insights into the functions of extracellular vesicle miRNAs and attempt to delineate the mechanism of miRNA sorting into extracellular vesicles and their immunomodulatory functions. Moreover, methodologies and strategies for miRNA delivery against infectious diseases are summarized. Finally, potential strategies for miRNA-based therapies are proposed.

Original languageEnglish (US)
Pages (from-to)706-732
Number of pages27
JournalMedicinal Research Reviews
Volume39
Issue number2
DOIs
StatePublished - Mar 2019

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Keywords

  • T cells
  • extracellular vesicles
  • immunity
  • infectious diseases
  • microRNAs
  • modulation

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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