Roles of MCP-1 in development of HIV-dementia

Navneet Kaur Dhillon, Rachel Williams, Shannon Callen, Chris Zien, Opendra Narayan, Shilpa J Buch

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

The encephalopathy caused by HIV, known clinically as HIV-associated dementia (HAD) and pathologically as HIV encephalitis (HIVE), results from intense infiltration of mononuclear cells, productive replication of the virus in monocyte-derived macrophages/microglia, abortive replication in astrocytes and activation of macrophages/microglia and astrocytes leading to neuronal degeneration in the brains of infected persons. Recent findings have suggested that development of HAD is based more on the activation process than on direct evidence of virus replication in the brain. Since HAD is based on the encephalitic process, major studies have been directed to the mechanisms regulating the inflammatory process. Monocyte chemoattractant protein 1, MCP-1, is a chemokine that is implicated in this process and also in the development of activation in the brain. In this review, we have attempted to identify mechanisms that induce expression of MCP-1 in the brain and the role that it plays in recruitment of mononuclear cells from blood to brain and in the activation processes of inflammatory and neural cells that lead to development of degenerative changes in the neuronal population.

Original languageEnglish (US)
Pages (from-to)3913-3918
Number of pages6
JournalFrontiers in Bioscience
Volume13
Issue number10
DOIs
StatePublished - May 2 2008

Fingerprint

AIDS Dementia Complex
Brain
Chemical activation
Macrophages
Microglia
Virus Replication
Viruses
Astrocytes
Macrophage Activation
Chemokine CCL2
Encephalitis
Chemokines
Infiltration
Blood Cells
Blood
HIV
Population

Keywords

  • Astrocytes
  • Blood brain barrier
  • HAD
  • HIV-1
  • Macrophages
  • Neurons
  • Review

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Dhillon, N. K., Williams, R., Callen, S., Zien, C., Narayan, O., & Buch, S. J. (2008). Roles of MCP-1 in development of HIV-dementia. Frontiers in Bioscience, 13(10), 3913-3918. https://doi.org/10.2741/2979

Roles of MCP-1 in development of HIV-dementia. / Dhillon, Navneet Kaur; Williams, Rachel; Callen, Shannon; Zien, Chris; Narayan, Opendra; Buch, Shilpa J.

In: Frontiers in Bioscience, Vol. 13, No. 10, 02.05.2008, p. 3913-3918.

Research output: Contribution to journalReview article

Dhillon, NK, Williams, R, Callen, S, Zien, C, Narayan, O & Buch, SJ 2008, 'Roles of MCP-1 in development of HIV-dementia', Frontiers in Bioscience, vol. 13, no. 10, pp. 3913-3918. https://doi.org/10.2741/2979
Dhillon NK, Williams R, Callen S, Zien C, Narayan O, Buch SJ. Roles of MCP-1 in development of HIV-dementia. Frontiers in Bioscience. 2008 May 2;13(10):3913-3918. https://doi.org/10.2741/2979
Dhillon, Navneet Kaur ; Williams, Rachel ; Callen, Shannon ; Zien, Chris ; Narayan, Opendra ; Buch, Shilpa J. / Roles of MCP-1 in development of HIV-dementia. In: Frontiers in Bioscience. 2008 ; Vol. 13, No. 10. pp. 3913-3918.
@article{5681fc0344cc4413bef73af64e24577b,
title = "Roles of MCP-1 in development of HIV-dementia",
abstract = "The encephalopathy caused by HIV, known clinically as HIV-associated dementia (HAD) and pathologically as HIV encephalitis (HIVE), results from intense infiltration of mononuclear cells, productive replication of the virus in monocyte-derived macrophages/microglia, abortive replication in astrocytes and activation of macrophages/microglia and astrocytes leading to neuronal degeneration in the brains of infected persons. Recent findings have suggested that development of HAD is based more on the activation process than on direct evidence of virus replication in the brain. Since HAD is based on the encephalitic process, major studies have been directed to the mechanisms regulating the inflammatory process. Monocyte chemoattractant protein 1, MCP-1, is a chemokine that is implicated in this process and also in the development of activation in the brain. In this review, we have attempted to identify mechanisms that induce expression of MCP-1 in the brain and the role that it plays in recruitment of mononuclear cells from blood to brain and in the activation processes of inflammatory and neural cells that lead to development of degenerative changes in the neuronal population.",
keywords = "Astrocytes, Blood brain barrier, HAD, HIV-1, Macrophages, Neurons, Review",
author = "Dhillon, {Navneet Kaur} and Rachel Williams and Shannon Callen and Chris Zien and Opendra Narayan and Buch, {Shilpa J}",
year = "2008",
month = "5",
day = "2",
doi = "10.2741/2979",
language = "English (US)",
volume = "13",
pages = "3913--3918",
journal = "Frontiers in Bioscience - Landmark",
issn = "1093-9946",
publisher = "Frontiers in Bioscience",
number = "10",

}

TY - JOUR

T1 - Roles of MCP-1 in development of HIV-dementia

AU - Dhillon, Navneet Kaur

AU - Williams, Rachel

AU - Callen, Shannon

AU - Zien, Chris

AU - Narayan, Opendra

AU - Buch, Shilpa J

PY - 2008/5/2

Y1 - 2008/5/2

N2 - The encephalopathy caused by HIV, known clinically as HIV-associated dementia (HAD) and pathologically as HIV encephalitis (HIVE), results from intense infiltration of mononuclear cells, productive replication of the virus in monocyte-derived macrophages/microglia, abortive replication in astrocytes and activation of macrophages/microglia and astrocytes leading to neuronal degeneration in the brains of infected persons. Recent findings have suggested that development of HAD is based more on the activation process than on direct evidence of virus replication in the brain. Since HAD is based on the encephalitic process, major studies have been directed to the mechanisms regulating the inflammatory process. Monocyte chemoattractant protein 1, MCP-1, is a chemokine that is implicated in this process and also in the development of activation in the brain. In this review, we have attempted to identify mechanisms that induce expression of MCP-1 in the brain and the role that it plays in recruitment of mononuclear cells from blood to brain and in the activation processes of inflammatory and neural cells that lead to development of degenerative changes in the neuronal population.

AB - The encephalopathy caused by HIV, known clinically as HIV-associated dementia (HAD) and pathologically as HIV encephalitis (HIVE), results from intense infiltration of mononuclear cells, productive replication of the virus in monocyte-derived macrophages/microglia, abortive replication in astrocytes and activation of macrophages/microglia and astrocytes leading to neuronal degeneration in the brains of infected persons. Recent findings have suggested that development of HAD is based more on the activation process than on direct evidence of virus replication in the brain. Since HAD is based on the encephalitic process, major studies have been directed to the mechanisms regulating the inflammatory process. Monocyte chemoattractant protein 1, MCP-1, is a chemokine that is implicated in this process and also in the development of activation in the brain. In this review, we have attempted to identify mechanisms that induce expression of MCP-1 in the brain and the role that it plays in recruitment of mononuclear cells from blood to brain and in the activation processes of inflammatory and neural cells that lead to development of degenerative changes in the neuronal population.

KW - Astrocytes

KW - Blood brain barrier

KW - HAD

KW - HIV-1

KW - Macrophages

KW - Neurons

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=42649085005&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42649085005&partnerID=8YFLogxK

U2 - 10.2741/2979

DO - 10.2741/2979

M3 - Review article

VL - 13

SP - 3913

EP - 3918

JO - Frontiers in Bioscience - Landmark

JF - Frontiers in Bioscience - Landmark

SN - 1093-9946

IS - 10

ER -