Roles in immune responses

Richa Hanamsagar, Sandra M. Cardona, Tammy L Kielian, Astrid E. Cardona

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Microglia are best known as the mononuclear phagocytes of the central nervous system (CNS) parenchyma. As a resident glial cell population, microglia play key roles during the initiation, propagation, and/or resolution of inflammation. Recently, the discovery that microglial cells continuously survey their local CNS environment in vivo improved our understanding of their immune-surveillance properties in health and disease. Microglial interactions with other elements of the immune system and resident cells of the CNS define a fine balance between neuroprotection and irreparable tissue damage. In this chapter we highlight the innate immune properties of microglia, with a focus on events that initiate an inflammatory response within the brain proper including, Toll-like receptors, inflammasomes, cytokines, and chemokines, and their relationship to immune-mediated disease exacerbation or resolution.

Original languageEnglish (US)
Title of host publicationMicroglia in Health and Disease
PublisherSpringer New York
Pages115-144
Number of pages30
ISBN (Electronic)9781493914296
ISBN (Print)1493914286, 9781493914289
DOIs
Publication statusPublished - Jul 1 2014

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Keywords

  • Antigen presentation
  • Blood-brain barrier
  • Chemokine
  • Inflammasome
  • Microglia
  • Nod-like receptor
  • Phagocytosis
  • Scavenging
  • Toll-like receptor

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Hanamsagar, R., Cardona, S. M., Kielian, T. L., & Cardona, A. E. (2014). Roles in immune responses. In Microglia in Health and Disease (pp. 115-144). Springer New York. https://doi.org/10.1007/978-1-4939-1429-6_5