Role of Staphylococcus protease in the development of influenza pneumonia

M. Tashiro, Pawel S Ciborowski, H. D. Klenk, G. Pulverer, R. Rott

Research output: Contribution to journalArticle

178 Citations (Scopus)

Abstract

In influenza the combined virus-bacterial pneumonia is approximately three times more common than primary viral pneumonia1. The bacteria most commonly involved are Staphylococcus aureus, Streptococcus pneumoniae and Haemophilus influenzae. S. aureus co-infection is reported to have a fatality rate of up to 42% (ref. 2). It is thought that virus infection in the respiratory tract favours growth conditions for bacteria. In this letter data are presented which show that some S. aureus strains secrete a protease which exerts a decisive influence on the outcome of influenza virus infection in mice by cleavage activation of the virus haemag-glutinin.

Original languageEnglish (US)
Pages (from-to)536-537
Number of pages2
JournalNature
Volume325
Issue number6104
DOIs
StatePublished - Jan 1 1987

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Virus Diseases
Orthomyxoviridae
Staphylococcus
Human Influenza
Staphylococcus aureus
Pneumonia
Peptide Hydrolases
Staphylococcal Pneumonia
Bacteria
Bacterial Pneumonia
Virus Activation
Haemophilus influenzae
Streptococcus pneumoniae
Coinfection
Respiratory System
Growth

ASJC Scopus subject areas

  • General

Cite this

Role of Staphylococcus protease in the development of influenza pneumonia. / Tashiro, M.; Ciborowski, Pawel S; Klenk, H. D.; Pulverer, G.; Rott, R.

In: Nature, Vol. 325, No. 6104, 01.01.1987, p. 536-537.

Research output: Contribution to journalArticle

Tashiro, M, Ciborowski, PS, Klenk, HD, Pulverer, G & Rott, R 1987, 'Role of Staphylococcus protease in the development of influenza pneumonia', Nature, vol. 325, no. 6104, pp. 536-537. https://doi.org/10.1038/325536a0
Tashiro, M. ; Ciborowski, Pawel S ; Klenk, H. D. ; Pulverer, G. ; Rott, R. / Role of Staphylococcus protease in the development of influenza pneumonia. In: Nature. 1987 ; Vol. 325, No. 6104. pp. 536-537.
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