Role of soybean-derived bioactive compounds in inflammatory bowel disease

Anthony F. Juritsch, Regis Moreau

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Inflammatory bowel disease (IBD) is a chronic, inflammatory condition of the gastrointestinal tract. Patients with IBD present with debilitating symptoms that alter the quality of life and can develop into severe complications requiring surgery. Epidemiological evidence indicates Westernized societies have an elevated IBD burden when compared with Asian societies. Considering the stark contrast between the typical Western and Eastern dietary patterns, it is postulated that differences in food and lifestyle contribute to lower IBD incidence in Asian countries. Soybeans (Glycine max), which are consumed in high quantities and as various preparations in Eastern societies, contain a wealth of natural, biologically active compounds that include isoflavones, bioactive peptides, protease inhibitors, and phytosterols, among many others. These compounds have been shown to improve human health, and preclinical evidence suggests they have potential to improve the prognosis of IBD. This review summarizes the current state of evidence regarding the effects and the mechanisms of action of these soybean-derived bioactive compounds in experimental models of IBD.

Original languageEnglish (US)
Pages (from-to)618-638
Number of pages21
JournalNutrition Reviews
Volume76
Issue number8
DOIs
StatePublished - Jan 1 2018

Fingerprint

Inflammatory Bowel Diseases
Soybeans
Phytosterols
Isoflavones
Protease Inhibitors
Gastrointestinal Tract
Life Style
Theoretical Models
Quality of Life
Food
Peptides
Incidence
Health

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Role of soybean-derived bioactive compounds in inflammatory bowel disease. / Juritsch, Anthony F.; Moreau, Regis.

In: Nutrition Reviews, Vol. 76, No. 8, 01.01.2018, p. 618-638.

Research output: Contribution to journalArticle

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