Role of paraventricular nucleus in mediating sympathetic outflow in heart failure

Research output: Contribution to journalReview article

98 Citations (Scopus)

Abstract

A number of neurohumoral processes are activated in heart failure, including an increase in the plasma concentration of norepinephrine. Few studies have been performed to examine the role of the central nervous system in the activation of sympathetic outflow during heart failure (HF). In this paper I review these limited studies, with particular emphasis on examining the role of the paraventricular nucleus (PVN) in the exaggerated sympathetic outflow commonly observed in heart failure. The conclusion is that heart failure is associated with changes in specific areas in the brain and that alterations in the activation of neurons in the PVN are likely related to abnormalities in vasopressin production, blood volume regulation, and sympathoexcitation observed in the heart failure state. Furthermore, neuronal nitric oxide within the PVN that is involved in mediating sympathetic outflow via a GABA mechanism from the PVN may be deficient in inhibiting overall sympathetic outflow leading to the exaggerated sympathetic outflow commonly observed in heart failure.

Original languageEnglish (US)
Pages (from-to)73-86
Number of pages14
JournalHeart Failure Reviews
Volume5
Issue number1
DOIs
StatePublished - May 29 2000

Fingerprint

Paraventricular Hypothalamic Nucleus
Heart Failure
Blood Volume
Vasopressins
gamma-Aminobutyric Acid
Norepinephrine
Nitric Oxide
Central Nervous System
Neurons
Brain

Keywords

  • GABA
  • Nitric oxide
  • Paraventricular nucleus
  • Sympathetic nerve activity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Role of paraventricular nucleus in mediating sympathetic outflow in heart failure. / Patel, Kaushik P.

In: Heart Failure Reviews, Vol. 5, No. 1, 29.05.2000, p. 73-86.

Research output: Contribution to journalReview article

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