Role of natural killer cells in tumor growth and metastasis

C57BL/6 normal and beige mice

James E Talmadge, K. M. Meyers, D. J. Prieur, J. R. Starkey

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

The role of natural killer (NK) cells in tumor growth and metastasis was studied in syngeneic normal and beige inbred C57BL/6 mice. Mice with the beige point mutation have been shown to be deficient in nonstimulated NK activity. Tumor-passaged B16 malignant melanoma cells were refractory to NK activity as determined by in vitro assay, but after in vitro culture they became sensitive to NK activity. The NK-insensitive B16 tumor grew and metastasized similarly in normal and beige mice. However, the NK-sensitive B16 tumors grew more slowly and produced fewer metastases in normal mice than in NK-deficient beige mice. Activation of NK cells by lymphocytic choriomeningitis virus infection decreased the rate of growth and number of metastases of both NK-sensitive and NK-insensitive tumors in both normal and beige mice. These results suggest the importance of NK cells as a determinant to tumor growth and metastasis.

Original languageEnglish (US)
Pages (from-to)929-935
Number of pages7
JournalJournal of the National Cancer Institute
Volume65
Issue number5
StatePublished - Dec 1 1980

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Natural Killer Cells
Neoplasm Metastasis
Growth
Neoplasms
Lymphocytic choriomeningitis virus
Experimental Melanomas
Virus Diseases
Inbred C57BL Mouse
Point Mutation
Melanoma
In Vitro Techniques

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Role of natural killer cells in tumor growth and metastasis : C57BL/6 normal and beige mice. / Talmadge, James E; Meyers, K. M.; Prieur, D. J.; Starkey, J. R.

In: Journal of the National Cancer Institute, Vol. 65, No. 5, 01.12.1980, p. 929-935.

Research output: Contribution to journalArticle

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