Role of mononuclear phagocytes in the pathogenesis of human immunodeficiency virus infection

M. S. Meltzer, D. R.P.J. Skillman Gomatos, D. C. Kalter, Howard Eliot Gendelman

Research output: Contribution to journalReview article

216 Citations (Scopus)

Abstract

We have presented evidence in this review for the following: (a) Macrophages are likely the first cell infected by HIV. Recovery of HIV from macrophages has been documented in the early stages of infection in which virus isolation in T cells is unseccessful and dectectable levels of antibodies against HIV are absent. (b) Macrophages are major reservoirs for HIV during all stages of infection. Unlike the lytic infection of T cells, HIV-infected macrophages show little or no virus-induced cytopathic effects. HIV-infected macrophages persist in tissue for extended periods of time (months) with large numbers of infectious particles contained within intracytoplasmic vacuoles. (c) Macrophages are a vector for the spread of infection to different tissues within the patient and between individuals. Several studies suggest a 'Trojan horse' role for HIV-infected macrophages in the dissemination of infectious particles. The predominant cell in most bodily fluids (alveolar fluid, colostrum, semen, vaginal secretions) is the macrophage. In semen, for example, the numbers of macrophages exceed those of lymphocytes by more than 20-fold. (d) Macrophages are major regulatory cells that control the pace and intensity of disease progression in HIV infection. Macrophages secretory products are implicated in the pathogenesis of CNS disease and in control of viral latency in HIV-infected T cells. This litany of events in which macrophages participate in HIV-infection in humans parallels similar observations in such animal lentivirus infections as visna-maedi or caprine arthritis-encephalitis viruses. HIV interacts with monocytes differently than with T cells. Understanding this interaction may more clearly define both the pathogenesis of HIV disease and strategies for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)169-194
Number of pages26
JournalAnnual Review of Immunology
Volume8
StatePublished - Jan 1 1990

Fingerprint

Virus Diseases
Phagocytes
Macrophages
HIV
T-Lymphocytes
Infection
Semen
HIV Infections
Progressive Interstitial Pneumonia of Sheep
Visna
Lentivirus Infections
Caprine Arthritis-Encephalitis Viruses
Virus Latency
Viruses
HIV Antibodies
Colostrum
Central Nervous System Diseases
Vacuoles
Disease Progression
Monocytes

Keywords

  • HIV
  • macrophages
  • pathogenesis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Role of mononuclear phagocytes in the pathogenesis of human immunodeficiency virus infection. / Meltzer, M. S.; Skillman Gomatos, D. R.P.J.; Kalter, D. C.; Gendelman, Howard Eliot.

In: Annual Review of Immunology, Vol. 8, 01.01.1990, p. 169-194.

Research output: Contribution to journalReview article

Meltzer, M. S. ; Skillman Gomatos, D. R.P.J. ; Kalter, D. C. ; Gendelman, Howard Eliot. / Role of mononuclear phagocytes in the pathogenesis of human immunodeficiency virus infection. In: Annual Review of Immunology. 1990 ; Vol. 8. pp. 169-194.
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