Role of mesenchymal stem cells in regenerative medicine

Application to bone and cartilage repair

Froilan Granero-Molto, Jared A. Weis, Lara Longobardi, Anna Spagnoli

Research output: Contribution to journalReview article

124 Citations (Scopus)

Abstract

Background: Mesenchymal stem cells (MSC) are multipotent cells with the ability to differentiate into mesenchyme-derived cells including osteoblasts and chondrocytes. Objective: To provide an overview and expert opinion on the in vivo ability of MSC to home into tissues, their regenerative properties and potential applications for cell-based therapies to treat bone and cartilage disorders. Methods: Data sources including the PubMed database, abstract booklets and conference proceedings were searched for publications pertinent to MSC and their properties with emphasis on the in vivo studies and clinical use in cartilage and bone regeneration and repair. The search included the most current information possible. Conclusion: MSC can migrate to injured tissues and some of their reparative properties are mediated by paracrine mechanisms including their immunomodulatory actions. MSC possess a critical potential in regenerative medicine for the treatment of skeletal diseases, such as osteoarthritis or fracture healing failure, where treatments are partially effective or palliative.

Original languageEnglish (US)
Pages (from-to)255-268
Number of pages14
JournalExpert Opinion on Biological Therapy
Volume8
Issue number3
DOIs
StatePublished - Mar 1 2008

Fingerprint

Regenerative Medicine
Cartilage
Stem cells
Mesenchymal Stromal Cells
Bone
Repair
Bone and Bones
Tissue
Pamphlets
Bone Regeneration
Fracture Healing
Information Storage and Retrieval
Osteoblasts
Expert Testimony
Mesoderm
Chondrocytes
Cell- and Tissue-Based Therapy
Treatment Failure
PubMed
Osteoarthritis

Keywords

  • Cell homing
  • Fracture healing
  • Immunomodulation
  • Mesenchymal stem cells
  • Osteoarthritis
  • Paracrine mechanism
  • Regenerative medicine

ASJC Scopus subject areas

  • Pharmacology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics
  • Immunology

Cite this

Role of mesenchymal stem cells in regenerative medicine : Application to bone and cartilage repair. / Granero-Molto, Froilan; Weis, Jared A.; Longobardi, Lara; Spagnoli, Anna.

In: Expert Opinion on Biological Therapy, Vol. 8, No. 3, 01.03.2008, p. 255-268.

Research output: Contribution to journalReview article

Granero-Molto, Froilan ; Weis, Jared A. ; Longobardi, Lara ; Spagnoli, Anna. / Role of mesenchymal stem cells in regenerative medicine : Application to bone and cartilage repair. In: Expert Opinion on Biological Therapy. 2008 ; Vol. 8, No. 3. pp. 255-268.
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