Role of Krüppel-like factors in leukocyte development, function, and disease

Zhuoxiao Cao, Xinghui Sun, Basak Icli, Akm Khyrul Wara, Mark W. Feinberg

Research output: Contribution to journalReview article

82 Citations (Scopus)

Abstract

The Krüppel-like transcription factor (KLF) family participates in diverse aspects of cellular growth, development, differentiation, and activation. Recently, several groups have identified new connections between the function of these factors and leukocyte responses in health and disease. Gene targeting of individual KLFs in mice has uncovered novel and unexpected physiologic roles among myeloid and lymphocyte cell lineage maturation, particularly in the bone marrow niche and blood. In addition, several KLF family members are downstream targets of stimuli and signaling pathways critical to T-cell trafficking, T regulatory cell differentiation or suppressor function, monocyte/ macrophage activation or renewal, and B memory cell maturation or activation. Indeed, KLFs have been implicated in subtypes of leukemia, lymphoma, auto-immunity, and in acute and chronic inflammatory disease states, such as atherosclerosis, diabetes, and airway inflammation, raising the possibility that KLFs and their upstream signals are of therapeutic interest. This review focuses on the relevant literature of Krüppel-like factors in leukocyte biology and their implications in clinical settings.

Original languageEnglish (US)
Pages (from-to)4404-4414
Number of pages11
JournalBlood
Volume116
Issue number22
DOIs
StatePublished - Nov 25 2010

Fingerprint

Leukocytes
Transcription Factors
Chemical activation
Critical Pathways
Gene Targeting
Macrophage Activation
Cell Lineage
Myeloid Cells
Growth and Development
Monocytes
Cell Differentiation
Immunity
Lymphoma
Atherosclerosis
Leukemia
Chronic Disease
T-cells
Lymphocytes
Macrophages
Bone Marrow

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Role of Krüppel-like factors in leukocyte development, function, and disease. / Cao, Zhuoxiao; Sun, Xinghui; Icli, Basak; Wara, Akm Khyrul; Feinberg, Mark W.

In: Blood, Vol. 116, No. 22, 25.11.2010, p. 4404-4414.

Research output: Contribution to journalReview article

Cao, Zhuoxiao ; Sun, Xinghui ; Icli, Basak ; Wara, Akm Khyrul ; Feinberg, Mark W. / Role of Krüppel-like factors in leukocyte development, function, and disease. In: Blood. 2010 ; Vol. 116, No. 22. pp. 4404-4414.
@article{558b3e49855f48419bf0bfab16e19dee,
title = "Role of Kr{\"u}ppel-like factors in leukocyte development, function, and disease",
abstract = "The Kr{\"u}ppel-like transcription factor (KLF) family participates in diverse aspects of cellular growth, development, differentiation, and activation. Recently, several groups have identified new connections between the function of these factors and leukocyte responses in health and disease. Gene targeting of individual KLFs in mice has uncovered novel and unexpected physiologic roles among myeloid and lymphocyte cell lineage maturation, particularly in the bone marrow niche and blood. In addition, several KLF family members are downstream targets of stimuli and signaling pathways critical to T-cell trafficking, T regulatory cell differentiation or suppressor function, monocyte/ macrophage activation or renewal, and B memory cell maturation or activation. Indeed, KLFs have been implicated in subtypes of leukemia, lymphoma, auto-immunity, and in acute and chronic inflammatory disease states, such as atherosclerosis, diabetes, and airway inflammation, raising the possibility that KLFs and their upstream signals are of therapeutic interest. This review focuses on the relevant literature of Kr{\"u}ppel-like factors in leukocyte biology and their implications in clinical settings.",
author = "Zhuoxiao Cao and Xinghui Sun and Basak Icli and Wara, {Akm Khyrul} and Feinberg, {Mark W.}",
year = "2010",
month = "11",
day = "25",
doi = "10.1182/blood-2010-05-285353",
language = "English (US)",
volume = "116",
pages = "4404--4414",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "22",

}

TY - JOUR

T1 - Role of Krüppel-like factors in leukocyte development, function, and disease

AU - Cao, Zhuoxiao

AU - Sun, Xinghui

AU - Icli, Basak

AU - Wara, Akm Khyrul

AU - Feinberg, Mark W.

PY - 2010/11/25

Y1 - 2010/11/25

N2 - The Krüppel-like transcription factor (KLF) family participates in diverse aspects of cellular growth, development, differentiation, and activation. Recently, several groups have identified new connections between the function of these factors and leukocyte responses in health and disease. Gene targeting of individual KLFs in mice has uncovered novel and unexpected physiologic roles among myeloid and lymphocyte cell lineage maturation, particularly in the bone marrow niche and blood. In addition, several KLF family members are downstream targets of stimuli and signaling pathways critical to T-cell trafficking, T regulatory cell differentiation or suppressor function, monocyte/ macrophage activation or renewal, and B memory cell maturation or activation. Indeed, KLFs have been implicated in subtypes of leukemia, lymphoma, auto-immunity, and in acute and chronic inflammatory disease states, such as atherosclerosis, diabetes, and airway inflammation, raising the possibility that KLFs and their upstream signals are of therapeutic interest. This review focuses on the relevant literature of Krüppel-like factors in leukocyte biology and their implications in clinical settings.

AB - The Krüppel-like transcription factor (KLF) family participates in diverse aspects of cellular growth, development, differentiation, and activation. Recently, several groups have identified new connections between the function of these factors and leukocyte responses in health and disease. Gene targeting of individual KLFs in mice has uncovered novel and unexpected physiologic roles among myeloid and lymphocyte cell lineage maturation, particularly in the bone marrow niche and blood. In addition, several KLF family members are downstream targets of stimuli and signaling pathways critical to T-cell trafficking, T regulatory cell differentiation or suppressor function, monocyte/ macrophage activation or renewal, and B memory cell maturation or activation. Indeed, KLFs have been implicated in subtypes of leukemia, lymphoma, auto-immunity, and in acute and chronic inflammatory disease states, such as atherosclerosis, diabetes, and airway inflammation, raising the possibility that KLFs and their upstream signals are of therapeutic interest. This review focuses on the relevant literature of Krüppel-like factors in leukocyte biology and their implications in clinical settings.

UR - http://www.scopus.com/inward/record.url?scp=78649455728&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649455728&partnerID=8YFLogxK

U2 - 10.1182/blood-2010-05-285353

DO - 10.1182/blood-2010-05-285353

M3 - Review article

VL - 116

SP - 4404

EP - 4414

JO - Blood

JF - Blood

SN - 0006-4971

IS - 22

ER -