Role of aldose reductase in the development of diabetes-associated complications

Peter F. Kador, Jin H. Kinoshita

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The aldose reductase-initiated intracellular accumulation of polyols has been clearly shown to have a hyperosmotic effect on the lens of experimental animals. Similar localized osmotic changes resulting in the onset of pathology may also occur in the nerve, corneal epithelium, and retinal pericytes. Except for experimental diabetic cataracts, however, the exact mechanism by which aldose reductase is involved in these diabetes-associated complications remains to be clarified.

Original languageEnglish (US)
Pages (from-to)8-12
Number of pages5
JournalThe American journal of medicine
Issue number5 SUPPL. 1
Publication statusPublished - Nov 15 1985


ASJC Scopus subject areas

  • Medicine(all)

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