Role of adenosine in the control of inflammatory events associated with acute and chronic neurodegenerative disorders

Jonathan D. Geiger, Lara Buscemi, Julie A. Fotheringham

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Throughout the body, but mainly in the periphery, adaptive and innate immune systems operate to help protect against a variety of physical and biological insults. The brain, however, is in a slightly different situation because it is encased by the skull. For many years it was thought that the brain was an organ privileged against both adaptive and immune reactions, so that adaptive immune system mediated inflammatory swelling occurs rarely, especially when and where there is an intact blood-brain barrier. The concept that the brain is immunologically privileged does not hold, however, for the innate immune system, which has been implicated increasingly in a variety of acute and chronic neurodegenerative disorders. The cells that mainly constitute the innate immune system in brain are phagocytic microglia, and in addition, astrocytes, endothelial cells, and neurons; all contribute to neuroinflammatory reactions.

Original languageEnglish (US)
Title of host publicationAdenosine Receptors
Subtitle of host publicationTherapeutic Aspects for Inflammatory and Immune Diseases
PublisherCRC Press
Pages213-236
Number of pages24
ISBN (Electronic)9781420005776
ISBN (Print)0849339995, 9780849339998
StatePublished - Jan 1 2006

Fingerprint

Neurodegenerative Diseases
Adenosine
Immune System
Brain
Microglia
Blood-Brain Barrier
Skull
Astrocytes
Endothelial Cells
Neurons

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Immunology and Microbiology(all)

Cite this

Geiger, J. D., Buscemi, L., & Fotheringham, J. A. (2006). Role of adenosine in the control of inflammatory events associated with acute and chronic neurodegenerative disorders. In Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases (pp. 213-236). CRC Press.

Role of adenosine in the control of inflammatory events associated with acute and chronic neurodegenerative disorders. / Geiger, Jonathan D.; Buscemi, Lara; Fotheringham, Julie A.

Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases. CRC Press, 2006. p. 213-236.

Research output: Chapter in Book/Report/Conference proceedingChapter

Geiger, JD, Buscemi, L & Fotheringham, JA 2006, Role of adenosine in the control of inflammatory events associated with acute and chronic neurodegenerative disorders. in Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases. CRC Press, pp. 213-236.
Geiger JD, Buscemi L, Fotheringham JA. Role of adenosine in the control of inflammatory events associated with acute and chronic neurodegenerative disorders. In Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases. CRC Press. 2006. p. 213-236
Geiger, Jonathan D. ; Buscemi, Lara ; Fotheringham, Julie A. / Role of adenosine in the control of inflammatory events associated with acute and chronic neurodegenerative disorders. Adenosine Receptors: Therapeutic Aspects for Inflammatory and Immune Diseases. CRC Press, 2006. pp. 213-236
@inbook{5fac0e589aa946acb5201f136788f301,
title = "Role of adenosine in the control of inflammatory events associated with acute and chronic neurodegenerative disorders",
abstract = "Throughout the body, but mainly in the periphery, adaptive and innate immune systems operate to help protect against a variety of physical and biological insults. The brain, however, is in a slightly different situation because it is encased by the skull. For many years it was thought that the brain was an organ privileged against both adaptive and immune reactions, so that adaptive immune system mediated inflammatory swelling occurs rarely, especially when and where there is an intact blood-brain barrier. The concept that the brain is immunologically privileged does not hold, however, for the innate immune system, which has been implicated increasingly in a variety of acute and chronic neurodegenerative disorders. The cells that mainly constitute the innate immune system in brain are phagocytic microglia, and in addition, astrocytes, endothelial cells, and neurons; all contribute to neuroinflammatory reactions.",
author = "Geiger, {Jonathan D.} and Lara Buscemi and Fotheringham, {Julie A.}",
year = "2006",
month = "1",
day = "1",
language = "English (US)",
isbn = "0849339995",
pages = "213--236",
booktitle = "Adenosine Receptors",
publisher = "CRC Press",

}

TY - CHAP

T1 - Role of adenosine in the control of inflammatory events associated with acute and chronic neurodegenerative disorders

AU - Geiger, Jonathan D.

AU - Buscemi, Lara

AU - Fotheringham, Julie A.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Throughout the body, but mainly in the periphery, adaptive and innate immune systems operate to help protect against a variety of physical and biological insults. The brain, however, is in a slightly different situation because it is encased by the skull. For many years it was thought that the brain was an organ privileged against both adaptive and immune reactions, so that adaptive immune system mediated inflammatory swelling occurs rarely, especially when and where there is an intact blood-brain barrier. The concept that the brain is immunologically privileged does not hold, however, for the innate immune system, which has been implicated increasingly in a variety of acute and chronic neurodegenerative disorders. The cells that mainly constitute the innate immune system in brain are phagocytic microglia, and in addition, astrocytes, endothelial cells, and neurons; all contribute to neuroinflammatory reactions.

AB - Throughout the body, but mainly in the periphery, adaptive and innate immune systems operate to help protect against a variety of physical and biological insults. The brain, however, is in a slightly different situation because it is encased by the skull. For many years it was thought that the brain was an organ privileged against both adaptive and immune reactions, so that adaptive immune system mediated inflammatory swelling occurs rarely, especially when and where there is an intact blood-brain barrier. The concept that the brain is immunologically privileged does not hold, however, for the innate immune system, which has been implicated increasingly in a variety of acute and chronic neurodegenerative disorders. The cells that mainly constitute the innate immune system in brain are phagocytic microglia, and in addition, astrocytes, endothelial cells, and neurons; all contribute to neuroinflammatory reactions.

UR - http://www.scopus.com/inward/record.url?scp=77953621790&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953621790&partnerID=8YFLogxK

M3 - Chapter

AN - SCOPUS:77953621790

SN - 0849339995

SN - 9780849339998

SP - 213

EP - 236

BT - Adenosine Receptors

PB - CRC Press

ER -