Role of activation of bradykinin B2 receptors in disruption of the blood-brain barrier during acute hypertension

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Cellular mechanisms which account for disruption of the blood-brain barrier during acute hypertension are not clear. The goal of this study was to determine the role of synthesis/release of bradykinin to activate B2 receptors in disruption of the blood-brain barrier during acute hypertension. Permeability of the blood-brain barrier was quantitated by clearance of fluorescent-labeled dextran before and during phenylephrine-induced acute hypertension in rats treated with vehicle and Hoe-140 (0.1 μM). Phenylephrine infusion increased arterial pressure, arteriolar diameter and clearance of fluorescent dextran by a similar magnitude in both groups. These findings suggest that disruption of the blood-brain barrier during acute hypertension is not related to the synthesis/release of bradykinin to activate B2 receptors.

Original languageEnglish (US)
Pages (from-to)337-341
Number of pages5
JournalBrain Research
Volume738
Issue number2
DOIs
StatePublished - Nov 4 1996

Fingerprint

Bradykinin B2 Receptors
Blood-Brain Barrier
Hypertension
Bradykinin
Phenylephrine
Dextrans
Permeability
Arterial Pressure

Keywords

  • FITC-dextran
  • Hoe-140
  • brain
  • cerebral microcirculation
  • cerebral venules
  • rat
  • vascular permeability

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Role of activation of bradykinin B2 receptors in disruption of the blood-brain barrier during acute hypertension. / Mayhan, William G.

In: Brain Research, Vol. 738, No. 2, 04.11.1996, p. 337-341.

Research output: Contribution to journalArticle

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