Abstract

Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) reflect the spectrum of neural impairments seen during chronic viral infection. Current research efforts focus on improving antiretroviral and adjunctive therapies, defining disease onset and progression, facilitating drug delivery, and halting neurodegeneration and viral resistance. Because HIV is species-specific, generating disease in small-animal models has proved challenging. After two decades of research, rodent HAND models now include those containing a human immune system. Antiviral responses, neuroinflammation and immunocyte blood-brain barrier (BBB) trafficking follow HIV infection in these rodent models. We review these and other rodent models of HAND and discuss their unmet potential in reflecting human pathobiology and in facilitating disease monitoring and therapeutic discoveries.

Original languageEnglish (US)
Pages (from-to)197-208
Number of pages12
JournalTrends in Neurosciences
Volume35
Issue number3
DOIs
StatePublished - Mar 1 2012

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Rodentia
HIV
Virus Diseases
Blood-Brain Barrier
Research
Antiviral Agents
Disease Progression
Immune System
Animal Models
Neurocognitive Disorders
Therapeutics
Pharmaceutical Preparations

Keywords

  • Cognitive impairment
  • HIV-associated neurocognitive disorders
  • Human immunodeficiency virus type one
  • Neuroinflammation
  • Rodent model

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Rodent models for HIV-associated neurocognitive disorders. / Gorantla, Santhi; Poluektova, Larisa Y; Gendelman, Howard Eliot.

In: Trends in Neurosciences, Vol. 35, No. 3, 01.03.2012, p. 197-208.

Research output: Contribution to journalReview article

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