Risk of secondary solid malignancies after allogeneic hematopoietic stem cell transplantation and preventive strategies

Janak Adhikari, Priyadarshani Sharma, Vijaya R Bhatt

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

The risk of secondary solid malignancies is increased after allogeneic hematopoietic stem cell transplantation (HSCT). The risk starts at about 10 years after HSCT and continues even 20 years later. The most common secondary malignancies include squamous cell carcinoma of skin, genitourinary tract and oral cavity; lung and breast cancers. The use of total body irradiation or conditioning chemotherapy, chronic graft-versus-host disease and duration since HSCT can influence the risk of secondary solid malignancies. Secondary solid malignancies are common causes of nonrelapse mortality in long-term survivors and may account for up to 10% of late deaths. Avoiding smoking, alcohol use and excess sun exposure may reduce the risk. Cancer prevention guidelines are largely consensus-driven and follow the recommendations for general population.

Original languageEnglish (US)
Pages (from-to)3175-3185
Number of pages11
JournalFuture Oncology
Volume11
Issue number23
DOIs
StatePublished - Jan 1 2015

Fingerprint

Hematopoietic Stem Cell Transplantation
Neoplasms
Whole-Body Irradiation
Graft vs Host Disease
Solar System
Survivors
Mouth
Squamous Cell Carcinoma
Lung Neoplasms
Consensus
Smoking
Alcohols
Guidelines
Breast Neoplasms
Drug Therapy
Skin
Mortality
Population

Keywords

  • allogeneic hematopoietic stem cell transplantation
  • prevention
  • risk factors
  • secondary solid malignancy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Risk of secondary solid malignancies after allogeneic hematopoietic stem cell transplantation and preventive strategies. / Adhikari, Janak; Sharma, Priyadarshani; Bhatt, Vijaya R.

In: Future Oncology, Vol. 11, No. 23, 01.01.2015, p. 3175-3185.

Research output: Contribution to journalReview article

@article{06bd77e525214557b676d0799712b492,
title = "Risk of secondary solid malignancies after allogeneic hematopoietic stem cell transplantation and preventive strategies",
abstract = "The risk of secondary solid malignancies is increased after allogeneic hematopoietic stem cell transplantation (HSCT). The risk starts at about 10 years after HSCT and continues even 20 years later. The most common secondary malignancies include squamous cell carcinoma of skin, genitourinary tract and oral cavity; lung and breast cancers. The use of total body irradiation or conditioning chemotherapy, chronic graft-versus-host disease and duration since HSCT can influence the risk of secondary solid malignancies. Secondary solid malignancies are common causes of nonrelapse mortality in long-term survivors and may account for up to 10{\%} of late deaths. Avoiding smoking, alcohol use and excess sun exposure may reduce the risk. Cancer prevention guidelines are largely consensus-driven and follow the recommendations for general population.",
keywords = "allogeneic hematopoietic stem cell transplantation, prevention, risk factors, secondary solid malignancy",
author = "Janak Adhikari and Priyadarshani Sharma and Bhatt, {Vijaya R}",
year = "2015",
month = "1",
day = "1",
doi = "10.2217/fon.15.252",
language = "English (US)",
volume = "11",
pages = "3175--3185",
journal = "Future Oncology",
issn = "1479-6694",
publisher = "Future Medicine Ltd.",
number = "23",

}

TY - JOUR

T1 - Risk of secondary solid malignancies after allogeneic hematopoietic stem cell transplantation and preventive strategies

AU - Adhikari, Janak

AU - Sharma, Priyadarshani

AU - Bhatt, Vijaya R

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The risk of secondary solid malignancies is increased after allogeneic hematopoietic stem cell transplantation (HSCT). The risk starts at about 10 years after HSCT and continues even 20 years later. The most common secondary malignancies include squamous cell carcinoma of skin, genitourinary tract and oral cavity; lung and breast cancers. The use of total body irradiation or conditioning chemotherapy, chronic graft-versus-host disease and duration since HSCT can influence the risk of secondary solid malignancies. Secondary solid malignancies are common causes of nonrelapse mortality in long-term survivors and may account for up to 10% of late deaths. Avoiding smoking, alcohol use and excess sun exposure may reduce the risk. Cancer prevention guidelines are largely consensus-driven and follow the recommendations for general population.

AB - The risk of secondary solid malignancies is increased after allogeneic hematopoietic stem cell transplantation (HSCT). The risk starts at about 10 years after HSCT and continues even 20 years later. The most common secondary malignancies include squamous cell carcinoma of skin, genitourinary tract and oral cavity; lung and breast cancers. The use of total body irradiation or conditioning chemotherapy, chronic graft-versus-host disease and duration since HSCT can influence the risk of secondary solid malignancies. Secondary solid malignancies are common causes of nonrelapse mortality in long-term survivors and may account for up to 10% of late deaths. Avoiding smoking, alcohol use and excess sun exposure may reduce the risk. Cancer prevention guidelines are largely consensus-driven and follow the recommendations for general population.

KW - allogeneic hematopoietic stem cell transplantation

KW - prevention

KW - risk factors

KW - secondary solid malignancy

UR - http://www.scopus.com/inward/record.url?scp=84964525401&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964525401&partnerID=8YFLogxK

U2 - 10.2217/fon.15.252

DO - 10.2217/fon.15.252

M3 - Review article

C2 - 26551415

AN - SCOPUS:84964525401

VL - 11

SP - 3175

EP - 3185

JO - Future Oncology

JF - Future Oncology

SN - 1479-6694

IS - 23

ER -