Risk factors in the pathogenesis of invasive group A streptococcal infections

Role of protective humoral immunity

Hesham E Basma, Anna Norrby-Teglund, Yajaira Guedez, Allison McGeer, Donald E. Low, Omar El-Ahmedy, Benjamin Schwartz, Malak Kotb

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

An impressive change in the epidemiology and severity of invasive group A streptococcal infections occurred in the 1980s, and the incidence of streptococcal toxic shock syndrome cases continues to rise. The reason for the resurgence of severe invasive cases remains a mystery - has there been a change in the pathogen or in host protective immunity? To address these questions, we have studied 33 patients with invasive infection caused by genotypically indistinguishable M1T1 strains of Streptococcus pyogenes who had different disease outcomes. Patients were classified as having severe (n = 21) and nonsevere (n = 12) invasive infections based on the presence or absence of shock and organ failure. Levels of anti-M1 bactericidal antibodies and of antistreptococcal superantigen neutralizing antibodies in plasma were significantly lower in both groups than in age- and geographically matched healthy controls (P < 0.01). Importantly, the levels of these protective antibodies in plasma samples from severe and nonsevere invasive cases were not different. Together the data suggest that low levels of protective antibodies may contribute to host susceptibility to invasive streptococcal infection but do not modulate disease outcome. Other immunogenetic factors that regulate superantigen responses may influence the severity of systemic manifestations associated with invasive streptococcal infection.

Original languageEnglish (US)
Pages (from-to)1871-1877
Number of pages7
JournalInfection and Immunity
Volume67
Issue number4
StatePublished - Apr 6 1999

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Streptococcal Infections
Humoral Immunity
Superantigens
Antibodies
Immunogenetics
Streptococcus pyogenes
Septic Shock
Infection
Neutralizing Antibodies
Immunity
Shock
Epidemiology
Age Groups
Incidence

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Basma, H. E., Norrby-Teglund, A., Guedez, Y., McGeer, A., Low, D. E., El-Ahmedy, O., ... Kotb, M. (1999). Risk factors in the pathogenesis of invasive group A streptococcal infections: Role of protective humoral immunity. Infection and Immunity, 67(4), 1871-1877.

Risk factors in the pathogenesis of invasive group A streptococcal infections : Role of protective humoral immunity. / Basma, Hesham E; Norrby-Teglund, Anna; Guedez, Yajaira; McGeer, Allison; Low, Donald E.; El-Ahmedy, Omar; Schwartz, Benjamin; Kotb, Malak.

In: Infection and Immunity, Vol. 67, No. 4, 06.04.1999, p. 1871-1877.

Research output: Contribution to journalArticle

Basma, HE, Norrby-Teglund, A, Guedez, Y, McGeer, A, Low, DE, El-Ahmedy, O, Schwartz, B & Kotb, M 1999, 'Risk factors in the pathogenesis of invasive group A streptococcal infections: Role of protective humoral immunity', Infection and Immunity, vol. 67, no. 4, pp. 1871-1877.
Basma HE, Norrby-Teglund A, Guedez Y, McGeer A, Low DE, El-Ahmedy O et al. Risk factors in the pathogenesis of invasive group A streptococcal infections: Role of protective humoral immunity. Infection and Immunity. 1999 Apr 6;67(4):1871-1877.
Basma, Hesham E ; Norrby-Teglund, Anna ; Guedez, Yajaira ; McGeer, Allison ; Low, Donald E. ; El-Ahmedy, Omar ; Schwartz, Benjamin ; Kotb, Malak. / Risk factors in the pathogenesis of invasive group A streptococcal infections : Role of protective humoral immunity. In: Infection and Immunity. 1999 ; Vol. 67, No. 4. pp. 1871-1877.
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