Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based case-control study

Cindy M. Chang, Sophia S. Wang, Bhavana J Dave, Smrati Jain, Mohammad A. Vasef, Dennis D. Weisenburger, Wendy Cozen, Scott Davis, Richard K. Severson, Charles F. Lynch, Nathaniel Rothman, James R. Cerhan, Patricia Hartge, Lindsay M. Morton

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The t(14;18) chromosomal translocation is the most common cytogenetic abnormality in non-Hodgkin lymphoma (NHL), occurring in 70-90% of follicular lymphomas (FL) and 30-50% of diffuse large B-cell lymphomas (DLBCL). Previous t(14;18)-NHL studies have not evaluated risk factors for NHL defined by both t(14;18) status and histology. In this population-based case-control study, t(14;18) status was determined in DLBCL cases using fluorescence in situ hybridization on paraffin-embedded tumor sections. Polytomous logistic regression was used to evaluate the association between a wide variety of exposures and t(14;18)-positive (N = 109) and -negative DLBCL (N = 125) and FL (N = 318), adjusting for sex, age, race, and study center. Taller height, more lifetime surgeries, and PCB180 exposure were associated with t(14;18)-positivity. Taller individuals (third tertile vs. first tertile) had elevated risks of t(14;18)-positive DLBCL (odds ratio [OR] = 1.8, 95% confidence interval [CI] 1.1-3.0) and FL (OR = 1.4, 95%CI 1.0-1.9) but not t(14;18)-negative DLBCL. Similar patterns were seen for individuals with more lifetime surgeries (13+ vs. 0-12 surgeries; t(14;18)-positive DLBCL OR = 1.4, 95%CI 0.7-2.7; FL OR = 1.6, 95%CI 1.1-2.5) and individuals exposed to PCB180 greater than 20.8 ng/g (t(14;18)-positive DLBCL OR = 1.3, 95%CI 0.6-2.9; FL OR = 1.7, 95%CI 1.0-2.8). In contrast, termite treatment and high alpha-chlordane levels were associated with t(14;18)-negative DLBCL only, suggesting that these exposures do not act through t(14;18). Our findings suggest that putative associations between NHL and height, surgeries, and PCB180 may be t(14;18)-mediated and provide support for case-subtyping based on molecular and histologic subtypes. Future efforts should focus on pooling data to confirm and extend previous research on risk factors for t(14;18)-NHL subtypes.

Original languageEnglish (US)
Pages (from-to)938-947
Number of pages10
JournalInternational Journal of Cancer
Volume129
Issue number4
DOIs
StatePublished - Aug 15 2011

Fingerprint

Lymphoma, Large B-Cell, Diffuse
Non-Hodgkin's Lymphoma
Case-Control Studies
Histology
Follicular Lymphoma
Odds Ratio
Confidence Intervals
Population
Chlordan
Isoptera
Genetic Translocation
Fluorescence In Situ Hybridization
Chromosome Aberrations
Paraffin
Meta-Analysis
Logistic Models
Research

Keywords

  • case-control studies
  • diffuse large B-cell lymphoma
  • etiology
  • follicular lymphoma
  • lymphoma
  • non-Hodgkin
  • translocation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based case-control study. / Chang, Cindy M.; Wang, Sophia S.; Dave, Bhavana J; Jain, Smrati; Vasef, Mohammad A.; Weisenburger, Dennis D.; Cozen, Wendy; Davis, Scott; Severson, Richard K.; Lynch, Charles F.; Rothman, Nathaniel; Cerhan, James R.; Hartge, Patricia; Morton, Lindsay M.

In: International Journal of Cancer, Vol. 129, No. 4, 15.08.2011, p. 938-947.

Research output: Contribution to journalArticle

Chang, CM, Wang, SS, Dave, BJ, Jain, S, Vasef, MA, Weisenburger, DD, Cozen, W, Davis, S, Severson, RK, Lynch, CF, Rothman, N, Cerhan, JR, Hartge, P & Morton, LM 2011, 'Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based case-control study', International Journal of Cancer, vol. 129, no. 4, pp. 938-947. https://doi.org/10.1002/ijc.25717
Chang, Cindy M. ; Wang, Sophia S. ; Dave, Bhavana J ; Jain, Smrati ; Vasef, Mohammad A. ; Weisenburger, Dennis D. ; Cozen, Wendy ; Davis, Scott ; Severson, Richard K. ; Lynch, Charles F. ; Rothman, Nathaniel ; Cerhan, James R. ; Hartge, Patricia ; Morton, Lindsay M. / Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based case-control study. In: International Journal of Cancer. 2011 ; Vol. 129, No. 4. pp. 938-947.
@article{f9d05479d0644d66b0ec7e327b55ba6e,
title = "Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based case-control study",
abstract = "The t(14;18) chromosomal translocation is the most common cytogenetic abnormality in non-Hodgkin lymphoma (NHL), occurring in 70-90{\%} of follicular lymphomas (FL) and 30-50{\%} of diffuse large B-cell lymphomas (DLBCL). Previous t(14;18)-NHL studies have not evaluated risk factors for NHL defined by both t(14;18) status and histology. In this population-based case-control study, t(14;18) status was determined in DLBCL cases using fluorescence in situ hybridization on paraffin-embedded tumor sections. Polytomous logistic regression was used to evaluate the association between a wide variety of exposures and t(14;18)-positive (N = 109) and -negative DLBCL (N = 125) and FL (N = 318), adjusting for sex, age, race, and study center. Taller height, more lifetime surgeries, and PCB180 exposure were associated with t(14;18)-positivity. Taller individuals (third tertile vs. first tertile) had elevated risks of t(14;18)-positive DLBCL (odds ratio [OR] = 1.8, 95{\%} confidence interval [CI] 1.1-3.0) and FL (OR = 1.4, 95{\%}CI 1.0-1.9) but not t(14;18)-negative DLBCL. Similar patterns were seen for individuals with more lifetime surgeries (13+ vs. 0-12 surgeries; t(14;18)-positive DLBCL OR = 1.4, 95{\%}CI 0.7-2.7; FL OR = 1.6, 95{\%}CI 1.1-2.5) and individuals exposed to PCB180 greater than 20.8 ng/g (t(14;18)-positive DLBCL OR = 1.3, 95{\%}CI 0.6-2.9; FL OR = 1.7, 95{\%}CI 1.0-2.8). In contrast, termite treatment and high alpha-chlordane levels were associated with t(14;18)-negative DLBCL only, suggesting that these exposures do not act through t(14;18). Our findings suggest that putative associations between NHL and height, surgeries, and PCB180 may be t(14;18)-mediated and provide support for case-subtyping based on molecular and histologic subtypes. Future efforts should focus on pooling data to confirm and extend previous research on risk factors for t(14;18)-NHL subtypes.",
keywords = "case-control studies, diffuse large B-cell lymphoma, etiology, follicular lymphoma, lymphoma, non-Hodgkin, translocation",
author = "Chang, {Cindy M.} and Wang, {Sophia S.} and Dave, {Bhavana J} and Smrati Jain and Vasef, {Mohammad A.} and Weisenburger, {Dennis D.} and Wendy Cozen and Scott Davis and Severson, {Richard K.} and Lynch, {Charles F.} and Nathaniel Rothman and Cerhan, {James R.} and Patricia Hartge and Morton, {Lindsay M.}",
year = "2011",
month = "8",
day = "15",
doi = "10.1002/ijc.25717",
language = "English (US)",
volume = "129",
pages = "938--947",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based case-control study

AU - Chang, Cindy M.

AU - Wang, Sophia S.

AU - Dave, Bhavana J

AU - Jain, Smrati

AU - Vasef, Mohammad A.

AU - Weisenburger, Dennis D.

AU - Cozen, Wendy

AU - Davis, Scott

AU - Severson, Richard K.

AU - Lynch, Charles F.

AU - Rothman, Nathaniel

AU - Cerhan, James R.

AU - Hartge, Patricia

AU - Morton, Lindsay M.

PY - 2011/8/15

Y1 - 2011/8/15

N2 - The t(14;18) chromosomal translocation is the most common cytogenetic abnormality in non-Hodgkin lymphoma (NHL), occurring in 70-90% of follicular lymphomas (FL) and 30-50% of diffuse large B-cell lymphomas (DLBCL). Previous t(14;18)-NHL studies have not evaluated risk factors for NHL defined by both t(14;18) status and histology. In this population-based case-control study, t(14;18) status was determined in DLBCL cases using fluorescence in situ hybridization on paraffin-embedded tumor sections. Polytomous logistic regression was used to evaluate the association between a wide variety of exposures and t(14;18)-positive (N = 109) and -negative DLBCL (N = 125) and FL (N = 318), adjusting for sex, age, race, and study center. Taller height, more lifetime surgeries, and PCB180 exposure were associated with t(14;18)-positivity. Taller individuals (third tertile vs. first tertile) had elevated risks of t(14;18)-positive DLBCL (odds ratio [OR] = 1.8, 95% confidence interval [CI] 1.1-3.0) and FL (OR = 1.4, 95%CI 1.0-1.9) but not t(14;18)-negative DLBCL. Similar patterns were seen for individuals with more lifetime surgeries (13+ vs. 0-12 surgeries; t(14;18)-positive DLBCL OR = 1.4, 95%CI 0.7-2.7; FL OR = 1.6, 95%CI 1.1-2.5) and individuals exposed to PCB180 greater than 20.8 ng/g (t(14;18)-positive DLBCL OR = 1.3, 95%CI 0.6-2.9; FL OR = 1.7, 95%CI 1.0-2.8). In contrast, termite treatment and high alpha-chlordane levels were associated with t(14;18)-negative DLBCL only, suggesting that these exposures do not act through t(14;18). Our findings suggest that putative associations between NHL and height, surgeries, and PCB180 may be t(14;18)-mediated and provide support for case-subtyping based on molecular and histologic subtypes. Future efforts should focus on pooling data to confirm and extend previous research on risk factors for t(14;18)-NHL subtypes.

AB - The t(14;18) chromosomal translocation is the most common cytogenetic abnormality in non-Hodgkin lymphoma (NHL), occurring in 70-90% of follicular lymphomas (FL) and 30-50% of diffuse large B-cell lymphomas (DLBCL). Previous t(14;18)-NHL studies have not evaluated risk factors for NHL defined by both t(14;18) status and histology. In this population-based case-control study, t(14;18) status was determined in DLBCL cases using fluorescence in situ hybridization on paraffin-embedded tumor sections. Polytomous logistic regression was used to evaluate the association between a wide variety of exposures and t(14;18)-positive (N = 109) and -negative DLBCL (N = 125) and FL (N = 318), adjusting for sex, age, race, and study center. Taller height, more lifetime surgeries, and PCB180 exposure were associated with t(14;18)-positivity. Taller individuals (third tertile vs. first tertile) had elevated risks of t(14;18)-positive DLBCL (odds ratio [OR] = 1.8, 95% confidence interval [CI] 1.1-3.0) and FL (OR = 1.4, 95%CI 1.0-1.9) but not t(14;18)-negative DLBCL. Similar patterns were seen for individuals with more lifetime surgeries (13+ vs. 0-12 surgeries; t(14;18)-positive DLBCL OR = 1.4, 95%CI 0.7-2.7; FL OR = 1.6, 95%CI 1.1-2.5) and individuals exposed to PCB180 greater than 20.8 ng/g (t(14;18)-positive DLBCL OR = 1.3, 95%CI 0.6-2.9; FL OR = 1.7, 95%CI 1.0-2.8). In contrast, termite treatment and high alpha-chlordane levels were associated with t(14;18)-negative DLBCL only, suggesting that these exposures do not act through t(14;18). Our findings suggest that putative associations between NHL and height, surgeries, and PCB180 may be t(14;18)-mediated and provide support for case-subtyping based on molecular and histologic subtypes. Future efforts should focus on pooling data to confirm and extend previous research on risk factors for t(14;18)-NHL subtypes.

KW - case-control studies

KW - diffuse large B-cell lymphoma

KW - etiology

KW - follicular lymphoma

KW - lymphoma

KW - non-Hodgkin

KW - translocation

UR - http://www.scopus.com/inward/record.url?scp=79959701852&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959701852&partnerID=8YFLogxK

U2 - 10.1002/ijc.25717

DO - 10.1002/ijc.25717

M3 - Article

VL - 129

SP - 938

EP - 947

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 4

ER -