Ring chromosome in parosteal osteosarcoma. Clinical and diagnostic significance

Jane F. Sinovic, Julia A. Bridge, James R. Neff

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

In this study, two specimens of a parosteal osteosarcoma, a rare primary bone neoplasm comprising only 3-6% of all osteosarcomas, were cytogenetically analyzed utilizing standard techniques. In contrast to the complex karyotypes previously reported in osteosarcoma, this particular histologic subtype was characterized by a single chromosomal aberration, a ring chromosome. Ring chromosomes have been described as characteristic for two other low-grade malignant mesenchymal neoplasms, well-differentiated liposarcoma and dermatofibrosarcoma protuberans. We propose that the observation of a ring chromosome in osteosarcoma also correlates with a low-grade malignant potential.

Original languageEnglish (US)
Pages (from-to)50-52
Number of pages3
JournalCancer genetics and cytogenetics
Volume62
Issue number1
DOIs
StatePublished - Aug 1992

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Ring Chromosomes
Osteosarcoma
Dermatofibrosarcoma
Liposarcoma
Bone Neoplasms
Karyotype
Chromosome Aberrations
Observation
Neoplasms

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Ring chromosome in parosteal osteosarcoma. Clinical and diagnostic significance. / Sinovic, Jane F.; Bridge, Julia A.; Neff, James R.

In: Cancer genetics and cytogenetics, Vol. 62, No. 1, 08.1992, p. 50-52.

Research output: Contribution to journalArticle

Sinovic, Jane F. ; Bridge, Julia A. ; Neff, James R. / Ring chromosome in parosteal osteosarcoma. Clinical and diagnostic significance. In: Cancer genetics and cytogenetics. 1992 ; Vol. 62, No. 1. pp. 50-52.
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