Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient with CCHF Infection

Nicole Espy, Unai Pérez-Sautu, Eva Ramírez De Arellano, Anabel Negredo, Michael R. Wiley, Sina Bavari, Marta Díaz Menendez, María Paz Sánchez-Seco, Gustavo Palacios

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The use of ribavirin to treat Crimean-Congo hemorrhagic fever virus (CCHFV) infection has been controversial, based on uncertainties about its antiviral efficacy in clinical case studies. We studied the effect of ribavirin treatment on viral populations in a recent case by deep-sequencing analysis of plasma samples obtained from a CCHFV-infected patient before, during, and after a 5-day regimen of ribavirin treatment. The CCHFV load dropped during ribavirin treatment, and subclonal diversity (transitions) and indels increased in viral genomes during treatment. Although the results are based on a single case, these data demonstrate the mutagenic effect of ribavirin on CCHFV in vivo.

Original languageEnglish (US)
Pages (from-to)1952-1956
Number of pages5
JournalJournal of Infectious Diseases
Volume217
Issue number12
DOIs
StatePublished - May 25 2018

Fingerprint

Crimean-Congo hemorrhagic fever virus
Ribavirin
Infection
Population
High-Throughput Nucleotide Sequencing
Viral Genome
Virus Diseases
Therapeutics
Uncertainty
Antiviral Agents

Keywords

  • Crimean-Congo hemorrhagic fever virus
  • ribavirin
  • viral genomics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient with CCHF Infection. / Espy, Nicole; Pérez-Sautu, Unai; De Arellano, Eva Ramírez; Negredo, Anabel; Wiley, Michael R.; Bavari, Sina; Menendez, Marta Díaz; Sánchez-Seco, María Paz; Palacios, Gustavo.

In: Journal of Infectious Diseases, Vol. 217, No. 12, 25.05.2018, p. 1952-1956.

Research output: Contribution to journalArticle

Espy, N, Pérez-Sautu, U, De Arellano, ER, Negredo, A, Wiley, MR, Bavari, S, Menendez, MD, Sánchez-Seco, MP & Palacios, G 2018, 'Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient with CCHF Infection', Journal of Infectious Diseases, vol. 217, no. 12, pp. 1952-1956. https://doi.org/10.1093/infdis/jiy163
Espy, Nicole ; Pérez-Sautu, Unai ; De Arellano, Eva Ramírez ; Negredo, Anabel ; Wiley, Michael R. ; Bavari, Sina ; Menendez, Marta Díaz ; Sánchez-Seco, María Paz ; Palacios, Gustavo. / Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient with CCHF Infection. In: Journal of Infectious Diseases. 2018 ; Vol. 217, No. 12. pp. 1952-1956.
@article{68df8b29cfac4b038008f6cd1c3c4e5d,
title = "Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient with CCHF Infection",
abstract = "The use of ribavirin to treat Crimean-Congo hemorrhagic fever virus (CCHFV) infection has been controversial, based on uncertainties about its antiviral efficacy in clinical case studies. We studied the effect of ribavirin treatment on viral populations in a recent case by deep-sequencing analysis of plasma samples obtained from a CCHFV-infected patient before, during, and after a 5-day regimen of ribavirin treatment. The CCHFV load dropped during ribavirin treatment, and subclonal diversity (transitions) and indels increased in viral genomes during treatment. Although the results are based on a single case, these data demonstrate the mutagenic effect of ribavirin on CCHFV in vivo.",
keywords = "Crimean-Congo hemorrhagic fever virus, ribavirin, viral genomics",
author = "Nicole Espy and Unai P{\'e}rez-Sautu and {De Arellano}, {Eva Ram{\'i}rez} and Anabel Negredo and Wiley, {Michael R.} and Sina Bavari and Menendez, {Marta D{\'i}az} and S{\'a}nchez-Seco, {Mar{\'i}a Paz} and Gustavo Palacios",
year = "2018",
month = "5",
day = "25",
doi = "10.1093/infdis/jiy163",
language = "English (US)",
volume = "217",
pages = "1952--1956",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Ribavirin Had Demonstrable Effects on the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) Population and Load in a Patient with CCHF Infection

AU - Espy, Nicole

AU - Pérez-Sautu, Unai

AU - De Arellano, Eva Ramírez

AU - Negredo, Anabel

AU - Wiley, Michael R.

AU - Bavari, Sina

AU - Menendez, Marta Díaz

AU - Sánchez-Seco, María Paz

AU - Palacios, Gustavo

PY - 2018/5/25

Y1 - 2018/5/25

N2 - The use of ribavirin to treat Crimean-Congo hemorrhagic fever virus (CCHFV) infection has been controversial, based on uncertainties about its antiviral efficacy in clinical case studies. We studied the effect of ribavirin treatment on viral populations in a recent case by deep-sequencing analysis of plasma samples obtained from a CCHFV-infected patient before, during, and after a 5-day regimen of ribavirin treatment. The CCHFV load dropped during ribavirin treatment, and subclonal diversity (transitions) and indels increased in viral genomes during treatment. Although the results are based on a single case, these data demonstrate the mutagenic effect of ribavirin on CCHFV in vivo.

AB - The use of ribavirin to treat Crimean-Congo hemorrhagic fever virus (CCHFV) infection has been controversial, based on uncertainties about its antiviral efficacy in clinical case studies. We studied the effect of ribavirin treatment on viral populations in a recent case by deep-sequencing analysis of plasma samples obtained from a CCHFV-infected patient before, during, and after a 5-day regimen of ribavirin treatment. The CCHFV load dropped during ribavirin treatment, and subclonal diversity (transitions) and indels increased in viral genomes during treatment. Although the results are based on a single case, these data demonstrate the mutagenic effect of ribavirin on CCHFV in vivo.

KW - Crimean-Congo hemorrhagic fever virus

KW - ribavirin

KW - viral genomics

UR - http://www.scopus.com/inward/record.url?scp=85048145857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048145857&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiy163

DO - 10.1093/infdis/jiy163

M3 - Article

C2 - 29584885

AN - SCOPUS:85048145857

VL - 217

SP - 1952

EP - 1956

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 12

ER -