Rhabdomyosarcoma of the female urogenital tract

Daniel M. Hays, R. Beverly Raney, Walter Lawrence, Edmund A. Gehan, Edward H. Soule, Melvin Tefft, Harold M. Maurer, Rhabdomyosarcoma Study Commitee Intergroup Rhabdomyosarcoma Study Commitee

Research output: Contribution to journalArticle

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Abstract

During the initial 6 yr (1972-1978) of the Intergroup Rhabdomyosarcoma Study (IRS), 27 patients with rhadomyosarcoma of the female urogenital tract were treated, and the results of therapy were evaluated on the basis of 3-7 yr of observation. By primary site these tumors were: bladder, 14; vagina, 9; vulva, 2; and cervix uterus, 2. Twenty-three patients presented with localized tumors; the four remaining patients (1 bladder, 1 vagina, and 2 cervix) had distant metastases at diagnosis. Two patients with bladder tumors underwent pelvic exenteration, local irradiation, and chemotherapy (2 yr), and were without relapse. Ten patients were treated by partial cystectomy and postoperative chemotherapy (with or without local irradiation) and fatal recurrence occurred in three. The remaining seven patients are disease-free for 36-74 mo (mean, 51.8 mo). Six of the eight patients with nondisseminated vaginal tumors were treated by initial pelvic exenteration (2), hysterectomy-vaginectomy (2), or hemivaginectomy (2). All received postoperative chemotherapy and three received local irradiation. Delayed hysterectomy-vaginectomy after primary chemotherapy was performed in the two additional patients with vaginal tumors. Relapse has occurred in one of these eight patients with localized vaginal disease. The remaining seven have been observed for 3-5.5 yr (mean, <4 yr). Two patients with vulval lesions treated by a combined therapy regimen are without recurrence. Our conclusion is that chemotherapy has significantly increased survival in females with urogenital tract rhabdomyosarcomas.

Original languageEnglish (US)
Pages (from-to)828-834
Number of pages7
JournalJournal of pediatric surgery
Volume16
Issue number6
DOIs
StatePublished - Dec 1981

Fingerprint

Rhabdomyosarcoma
Drug Therapy
Pelvic Exenteration
Recurrence
Vagina
Hysterectomy
Urinary Bladder Neoplasms
Cervix Uteri
Vaginal Diseases
Neoplasms
Vulva
Cystectomy
Urinary Bladder
Observation
Neoplasm Metastasis
Survival

Keywords

  • Rhabdomyosarcoma
  • female urogenital rhabdomyosarcoma

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Hays, D. M., Raney, R. B., Lawrence, W., Gehan, E. A., Soule, E. H., Tefft, M., ... Intergroup Rhabdomyosarcoma Study Commitee, R. S. C. (1981). Rhabdomyosarcoma of the female urogenital tract. Journal of pediatric surgery, 16(6), 828-834. https://doi.org/10.1016/S0022-3468(81)80828-7

Rhabdomyosarcoma of the female urogenital tract. / Hays, Daniel M.; Raney, R. Beverly; Lawrence, Walter; Gehan, Edmund A.; Soule, Edward H.; Tefft, Melvin; Maurer, Harold M.; Intergroup Rhabdomyosarcoma Study Commitee, Rhabdomyosarcoma Study Commitee.

In: Journal of pediatric surgery, Vol. 16, No. 6, 12.1981, p. 828-834.

Research output: Contribution to journalArticle

Hays, DM, Raney, RB, Lawrence, W, Gehan, EA, Soule, EH, Tefft, M, Maurer, HM & Intergroup Rhabdomyosarcoma Study Commitee, RSC 1981, 'Rhabdomyosarcoma of the female urogenital tract', Journal of pediatric surgery, vol. 16, no. 6, pp. 828-834. https://doi.org/10.1016/S0022-3468(81)80828-7
Hays DM, Raney RB, Lawrence W, Gehan EA, Soule EH, Tefft M et al. Rhabdomyosarcoma of the female urogenital tract. Journal of pediatric surgery. 1981 Dec;16(6):828-834. https://doi.org/10.1016/S0022-3468(81)80828-7
Hays, Daniel M. ; Raney, R. Beverly ; Lawrence, Walter ; Gehan, Edmund A. ; Soule, Edward H. ; Tefft, Melvin ; Maurer, Harold M. ; Intergroup Rhabdomyosarcoma Study Commitee, Rhabdomyosarcoma Study Commitee. / Rhabdomyosarcoma of the female urogenital tract. In: Journal of pediatric surgery. 1981 ; Vol. 16, No. 6. pp. 828-834.
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abstract = "During the initial 6 yr (1972-1978) of the Intergroup Rhabdomyosarcoma Study (IRS), 27 patients with rhadomyosarcoma of the female urogenital tract were treated, and the results of therapy were evaluated on the basis of 3-7 yr of observation. By primary site these tumors were: bladder, 14; vagina, 9; vulva, 2; and cervix uterus, 2. Twenty-three patients presented with localized tumors; the four remaining patients (1 bladder, 1 vagina, and 2 cervix) had distant metastases at diagnosis. Two patients with bladder tumors underwent pelvic exenteration, local irradiation, and chemotherapy (2 yr), and were without relapse. Ten patients were treated by partial cystectomy and postoperative chemotherapy (with or without local irradiation) and fatal recurrence occurred in three. The remaining seven patients are disease-free for 36-74 mo (mean, 51.8 mo). Six of the eight patients with nondisseminated vaginal tumors were treated by initial pelvic exenteration (2), hysterectomy-vaginectomy (2), or hemivaginectomy (2). All received postoperative chemotherapy and three received local irradiation. Delayed hysterectomy-vaginectomy after primary chemotherapy was performed in the two additional patients with vaginal tumors. Relapse has occurred in one of these eight patients with localized vaginal disease. The remaining seven have been observed for 3-5.5 yr (mean, <4 yr). Two patients with vulval lesions treated by a combined therapy regimen are without recurrence. Our conclusion is that chemotherapy has significantly increased survival in females with urogenital tract rhabdomyosarcomas.",
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