Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game

Christopher J. Hyatt, Michal Assaf, Christine E. Muska, Rivkah I. Rosen, Andre D. Thomas, Matthew R Johnson, Jennifer L. Hylton, Melissa M. Andrews, Brady A. Reynolds, John H. Krystal, Marc N. Potenza, Godfrey D. Pearlson

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear. We assessed blood-oxygenation-level dependent (BOLD) signal in ventral and dorsal striatum during functional magnetic resonance imaging (fMRI) in current (CCD; n = 30) and former (FCD; n = 28) cocaine dependent subjects as well as healthy control (HC; n = 31) subjects while playing an interactive competitive Domino game involving risk-taking and reward/punishment processing. Out-of-scanner impulsivity-related measures were also collected. Although both FCD and CCD subjects scored significantly higher on impulsivity-related measures than did HC subjects, only FCD subjects had differences in striatal activation, specifically showing hypoactivation during their response to gains versus losses in right dorsal caudate, a brain region linked to habituation, cocaine craving and addiction maintenance. Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward. These findings suggest that remitted cocaine dependence is associated with striatal dysfunction during social reward processing in a manner linked to compulsivity and reward sensitivity measures. Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses).

Original languageEnglish (US)
Article numbere34917
JournalPloS one
Volume7
Issue number5
DOIs
StatePublished - May 14 2012

Fingerprint

Corpus Striatum
cocaine
Cocaine-Related Disorders
Reward
Cocaine
Impulsive Behavior
Charge coupled devices
Processing
craving
Punishment
Risk-Taking
Oxygenation
relapse
scanners
magnetic resonance imaging
Maintenance
Magnetic Resonance Imaging
Brain
Blood
Recurrence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game. / Hyatt, Christopher J.; Assaf, Michal; Muska, Christine E.; Rosen, Rivkah I.; Thomas, Andre D.; Johnson, Matthew R; Hylton, Jennifer L.; Andrews, Melissa M.; Reynolds, Brady A.; Krystal, John H.; Potenza, Marc N.; Pearlson, Godfrey D.

In: PloS one, Vol. 7, No. 5, e34917, 14.05.2012.

Research output: Contribution to journalArticle

Hyatt, CJ, Assaf, M, Muska, CE, Rosen, RI, Thomas, AD, Johnson, MR, Hylton, JL, Andrews, MM, Reynolds, BA, Krystal, JH, Potenza, MN & Pearlson, GD 2012, 'Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game', PloS one, vol. 7, no. 5, e34917. https://doi.org/10.1371/journal.pone.0034917
Hyatt, Christopher J. ; Assaf, Michal ; Muska, Christine E. ; Rosen, Rivkah I. ; Thomas, Andre D. ; Johnson, Matthew R ; Hylton, Jennifer L. ; Andrews, Melissa M. ; Reynolds, Brady A. ; Krystal, John H. ; Potenza, Marc N. ; Pearlson, Godfrey D. / Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game. In: PloS one. 2012 ; Vol. 7, No. 5.
@article{45852e037b674a4ea9a392c031b64eb6,
title = "Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game",
abstract = "Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear. We assessed blood-oxygenation-level dependent (BOLD) signal in ventral and dorsal striatum during functional magnetic resonance imaging (fMRI) in current (CCD; n = 30) and former (FCD; n = 28) cocaine dependent subjects as well as healthy control (HC; n = 31) subjects while playing an interactive competitive Domino game involving risk-taking and reward/punishment processing. Out-of-scanner impulsivity-related measures were also collected. Although both FCD and CCD subjects scored significantly higher on impulsivity-related measures than did HC subjects, only FCD subjects had differences in striatal activation, specifically showing hypoactivation during their response to gains versus losses in right dorsal caudate, a brain region linked to habituation, cocaine craving and addiction maintenance. Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward. These findings suggest that remitted cocaine dependence is associated with striatal dysfunction during social reward processing in a manner linked to compulsivity and reward sensitivity measures. Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses).",
author = "Hyatt, {Christopher J.} and Michal Assaf and Muska, {Christine E.} and Rosen, {Rivkah I.} and Thomas, {Andre D.} and Johnson, {Matthew R} and Hylton, {Jennifer L.} and Andrews, {Melissa M.} and Reynolds, {Brady A.} and Krystal, {John H.} and Potenza, {Marc N.} and Pearlson, {Godfrey D.}",
year = "2012",
month = "5",
day = "14",
doi = "10.1371/journal.pone.0034917",
language = "English (US)",
volume = "7",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

TY - JOUR

T1 - Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game

AU - Hyatt, Christopher J.

AU - Assaf, Michal

AU - Muska, Christine E.

AU - Rosen, Rivkah I.

AU - Thomas, Andre D.

AU - Johnson, Matthew R

AU - Hylton, Jennifer L.

AU - Andrews, Melissa M.

AU - Reynolds, Brady A.

AU - Krystal, John H.

AU - Potenza, Marc N.

AU - Pearlson, Godfrey D.

PY - 2012/5/14

Y1 - 2012/5/14

N2 - Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear. We assessed blood-oxygenation-level dependent (BOLD) signal in ventral and dorsal striatum during functional magnetic resonance imaging (fMRI) in current (CCD; n = 30) and former (FCD; n = 28) cocaine dependent subjects as well as healthy control (HC; n = 31) subjects while playing an interactive competitive Domino game involving risk-taking and reward/punishment processing. Out-of-scanner impulsivity-related measures were also collected. Although both FCD and CCD subjects scored significantly higher on impulsivity-related measures than did HC subjects, only FCD subjects had differences in striatal activation, specifically showing hypoactivation during their response to gains versus losses in right dorsal caudate, a brain region linked to habituation, cocaine craving and addiction maintenance. Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward. These findings suggest that remitted cocaine dependence is associated with striatal dysfunction during social reward processing in a manner linked to compulsivity and reward sensitivity measures. Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses).

AB - Cocaine addiction is characterized by impulsivity, impaired social relationships, and abnormal mesocorticolimbic reward processing, but their interrelationships relative to stages of cocaine addiction are unclear. We assessed blood-oxygenation-level dependent (BOLD) signal in ventral and dorsal striatum during functional magnetic resonance imaging (fMRI) in current (CCD; n = 30) and former (FCD; n = 28) cocaine dependent subjects as well as healthy control (HC; n = 31) subjects while playing an interactive competitive Domino game involving risk-taking and reward/punishment processing. Out-of-scanner impulsivity-related measures were also collected. Although both FCD and CCD subjects scored significantly higher on impulsivity-related measures than did HC subjects, only FCD subjects had differences in striatal activation, specifically showing hypoactivation during their response to gains versus losses in right dorsal caudate, a brain region linked to habituation, cocaine craving and addiction maintenance. Right caudate activity in FCD subjects also correlated negatively with impulsivity-related measures of self-reported compulsivity and sensitivity to reward. These findings suggest that remitted cocaine dependence is associated with striatal dysfunction during social reward processing in a manner linked to compulsivity and reward sensitivity measures. Future research should investigate the extent to which such differences might reflect underlying vulnerabilities linked to cocaine-using propensities (e.g., relapses).

UR - http://www.scopus.com/inward/record.url?scp=84860996013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860996013&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0034917

DO - 10.1371/journal.pone.0034917

M3 - Article

VL - 7

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 5

M1 - e34917

ER -