REVERSIBILITY OF LYMPHOMAS AND LYMPHOPROLIFERATIVE LESIONS DEVELOPING UNDER CYCLOSPORIN-STEROID THERAPY

T. E. Starzl, K. A. Porter, S. Iwatsuki, J. T. Rosenthal, Byers Wendell Shaw Jr, R. W. Atchison, M. A. Nalesnik, M. Ho, B. P. Griffith, T. R. Hakala, R. L. Hardesty, R. Jaffe, H. T. Bahnson

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Abstract

Post-transplant lymphomas or other lymphoproliferative lesions, which were usually associated with Epstein-Barr virus infections, developed in 8, 4, 3, and 2 recipients, respectively, of cadaveric kidney, liver, heart, and heart-lung homografts. Reduction or discontinuance of immunosuppression caused regression of the lesions, often without subsequent rejection of the grafts. Chemotherapy and irradiation were not valuable. The findings may influence policies about treating other kinds of post-transplantation neoplasms.

Original languageEnglish (US)
Pages (from-to)583-587
Number of pages5
JournalThe Lancet
Volume323
Issue number8377
DOIs
StatePublished - Mar 17 1984

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Neoplasm Transplantation
Cyclosporine
Lymphoma
Steroids
Epstein-Barr Virus Infections
Graft Rejection
Immunosuppression
Allografts
Transplants
Kidney
Drug Therapy
Lung
Liver
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Starzl, T. E., Porter, K. A., Iwatsuki, S., Rosenthal, J. T., Shaw Jr, B. W., Atchison, R. W., ... Bahnson, H. T. (1984). REVERSIBILITY OF LYMPHOMAS AND LYMPHOPROLIFERATIVE LESIONS DEVELOPING UNDER CYCLOSPORIN-STEROID THERAPY. The Lancet, 323(8377), 583-587. https://doi.org/10.1016/S0140-6736(84)90994-2

REVERSIBILITY OF LYMPHOMAS AND LYMPHOPROLIFERATIVE LESIONS DEVELOPING UNDER CYCLOSPORIN-STEROID THERAPY. / Starzl, T. E.; Porter, K. A.; Iwatsuki, S.; Rosenthal, J. T.; Shaw Jr, Byers Wendell; Atchison, R. W.; Nalesnik, M. A.; Ho, M.; Griffith, B. P.; Hakala, T. R.; Hardesty, R. L.; Jaffe, R.; Bahnson, H. T.

In: The Lancet, Vol. 323, No. 8377, 17.03.1984, p. 583-587.

Research output: Contribution to journalArticle

Starzl, TE, Porter, KA, Iwatsuki, S, Rosenthal, JT, Shaw Jr, BW, Atchison, RW, Nalesnik, MA, Ho, M, Griffith, BP, Hakala, TR, Hardesty, RL, Jaffe, R & Bahnson, HT 1984, 'REVERSIBILITY OF LYMPHOMAS AND LYMPHOPROLIFERATIVE LESIONS DEVELOPING UNDER CYCLOSPORIN-STEROID THERAPY', The Lancet, vol. 323, no. 8377, pp. 583-587. https://doi.org/10.1016/S0140-6736(84)90994-2
Starzl TE, Porter KA, Iwatsuki S, Rosenthal JT, Shaw Jr BW, Atchison RW et al. REVERSIBILITY OF LYMPHOMAS AND LYMPHOPROLIFERATIVE LESIONS DEVELOPING UNDER CYCLOSPORIN-STEROID THERAPY. The Lancet. 1984 Mar 17;323(8377):583-587. https://doi.org/10.1016/S0140-6736(84)90994-2
Starzl, T. E. ; Porter, K. A. ; Iwatsuki, S. ; Rosenthal, J. T. ; Shaw Jr, Byers Wendell ; Atchison, R. W. ; Nalesnik, M. A. ; Ho, M. ; Griffith, B. P. ; Hakala, T. R. ; Hardesty, R. L. ; Jaffe, R. ; Bahnson, H. T. / REVERSIBILITY OF LYMPHOMAS AND LYMPHOPROLIFERATIVE LESIONS DEVELOPING UNDER CYCLOSPORIN-STEROID THERAPY. In: The Lancet. 1984 ; Vol. 323, No. 8377. pp. 583-587.
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