Retinoid metabolism during development of liver cirrhosis

Sathish Kumar Natarajan, Simmy Thomas, Anup Ramachandran, Anna B. Pulimood, Kunnissery A. Balasubramanian

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The changes in retinoid metabolism have been documented in liver cirrhosis. However, the dynamic alterations in levels of this vitamin between circulation and liver during development of the liver cirrhosis are not well understood. The aim of this study was to measure retinoids in the liver and circulation in parallel, during and after development of cirrhosis induced by carbon tetrachloride and thioacetamide. Retinoid levels were measured by HPLC. A decrease in retinaldehyde and total retinol, together with an increase in retinoic acid was evident in liver from both carbon tetrachloride or thioacetamide treated rats within a month after initiation of treatment. Activity of enzymes involved in retinoid metabolism such as retinaldehyde oxidase, retinaldehyde dehydrogenase, and retinaldehyde reductase were decreased in the liver. In parallel, levels of retinol and retinaldehyde in the serum were increased while retinoic acid was decreased. This study indicates that during development of cirrhosis, there is reciprocal transfer of retinoid metabolites between the circulation and the liver.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalArchives of Biochemistry and Biophysics
Volume443
Issue number1-2
DOIs
StatePublished - Nov 15 2005

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Retinaldehyde
Retinoids
Metabolism
Liver Cirrhosis
Liver
Liver Circulation
Thioacetamide
Oxidoreductases
Carbon Tetrachloride
Tretinoin
Vitamin A
Fibrosis
Vitamins
High Pressure Liquid Chromatography
Metabolites
Rats
Enzymes
Serum

Keywords

  • Metabolizing enzymes
  • Retinaldehyde
  • Retinoic acid
  • Retinol

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

Cite this

Natarajan, S. K., Thomas, S., Ramachandran, A., Pulimood, A. B., & Balasubramanian, K. A. (2005). Retinoid metabolism during development of liver cirrhosis. Archives of Biochemistry and Biophysics, 443(1-2), 93-100. https://doi.org/10.1016/j.abb.2005.09.008

Retinoid metabolism during development of liver cirrhosis. / Natarajan, Sathish Kumar; Thomas, Simmy; Ramachandran, Anup; Pulimood, Anna B.; Balasubramanian, Kunnissery A.

In: Archives of Biochemistry and Biophysics, Vol. 443, No. 1-2, 15.11.2005, p. 93-100.

Research output: Contribution to journalArticle

Natarajan, SK, Thomas, S, Ramachandran, A, Pulimood, AB & Balasubramanian, KA 2005, 'Retinoid metabolism during development of liver cirrhosis', Archives of Biochemistry and Biophysics, vol. 443, no. 1-2, pp. 93-100. https://doi.org/10.1016/j.abb.2005.09.008
Natarajan, Sathish Kumar ; Thomas, Simmy ; Ramachandran, Anup ; Pulimood, Anna B. ; Balasubramanian, Kunnissery A. / Retinoid metabolism during development of liver cirrhosis. In: Archives of Biochemistry and Biophysics. 2005 ; Vol. 443, No. 1-2. pp. 93-100.
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