Retinal prosthesis for the blind

Eyal Margalit, Mauricio Maia, James D. Weiland, Robert J. Greenberg, Gildo Y. Fujii, Gustavo Torres, Duke V. Piyathaisere, Thomas M. O'Hearn, Wentai Liu, Gianluca Lazzi, Gislin Dagnelie, Dean A. Scribner, Eugene De Juan, Mark S. Humayun

Research output: Contribution to journalReview article

340 Citations (Scopus)

Abstract

Most of current concepts for a visual prosthesis are based on neuronal electrical stimulation at different locations along the visual pathways within the central nervous system. The different designs of visual prostheses are named according to their locations (i.e., cortical, optic nerve, subretinal, and epiretinal). Visual loss caused by outer retinal degeneration in diseases such as retinitis pigmentosa or age-related macular degeneration can be reversed by electrical stimulation of the retina or the optic nerve (retinal or optic nerve prostheses, respectively). On the other hand, visual loss caused by inner or whole thickness retinal diseases, eye loss, optic nerve diseases (tumors, ischemia, inflammatory processes etc.), or diseases of the central nervous system (not including diseases of the primary and secondary visual cortices) can be reversed by a cortical visual prosthesis. The intent of this article is to provide an overview of current and future concepts of retinal and optic nerve prostheses. This article will begin with general considerations that are related to all or most of visual prostheses and then concentrate on the retinal and optic nerve designs. The authors believe that the field has grown beyond the scope of a single article so cortical prostheses will be described only because of their direct effect on the concept and technical development of the other prostheses, and this will be done in a more general and historic perspective.

Original languageEnglish (US)
Pages (from-to)335-356
Number of pages22
JournalSurvey of Ophthalmology
Volume47
Issue number4
DOIs
StatePublished - Aug 24 2002

Fingerprint

Visual Prosthesis
Optic Nerve
Prostheses and Implants
Electric Stimulation
Retinal Diseases
Optic Nerve Diseases
Retinal Degeneration
Retinitis Pigmentosa
Visual Pathways
Central Nervous System Diseases
Macular Degeneration
Visual Cortex
Retina
Ischemia
Central Nervous System
Neoplasms

Keywords

  • Artificial vision
  • Blindness
  • Cortical prosthesis
  • Electrical stimulation
  • Electronic implants
  • Macular degeneration
  • Optic nerve
  • Optic nerve prosthesis
  • Retina
  • Retinal prosthesis
  • Retinitis pigmentosa
  • Visual cortex
  • Visual prosthesis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Margalit, E., Maia, M., Weiland, J. D., Greenberg, R. J., Fujii, G. Y., Torres, G., ... Humayun, M. S. (2002). Retinal prosthesis for the blind. Survey of Ophthalmology, 47(4), 335-356. https://doi.org/10.1016/S0039-6257(02)00311-9

Retinal prosthesis for the blind. / Margalit, Eyal; Maia, Mauricio; Weiland, James D.; Greenberg, Robert J.; Fujii, Gildo Y.; Torres, Gustavo; Piyathaisere, Duke V.; O'Hearn, Thomas M.; Liu, Wentai; Lazzi, Gianluca; Dagnelie, Gislin; Scribner, Dean A.; De Juan, Eugene; Humayun, Mark S.

In: Survey of Ophthalmology, Vol. 47, No. 4, 24.08.2002, p. 335-356.

Research output: Contribution to journalReview article

Margalit, E, Maia, M, Weiland, JD, Greenberg, RJ, Fujii, GY, Torres, G, Piyathaisere, DV, O'Hearn, TM, Liu, W, Lazzi, G, Dagnelie, G, Scribner, DA, De Juan, E & Humayun, MS 2002, 'Retinal prosthesis for the blind', Survey of Ophthalmology, vol. 47, no. 4, pp. 335-356. https://doi.org/10.1016/S0039-6257(02)00311-9
Margalit E, Maia M, Weiland JD, Greenberg RJ, Fujii GY, Torres G et al. Retinal prosthesis for the blind. Survey of Ophthalmology. 2002 Aug 24;47(4):335-356. https://doi.org/10.1016/S0039-6257(02)00311-9
Margalit, Eyal ; Maia, Mauricio ; Weiland, James D. ; Greenberg, Robert J. ; Fujii, Gildo Y. ; Torres, Gustavo ; Piyathaisere, Duke V. ; O'Hearn, Thomas M. ; Liu, Wentai ; Lazzi, Gianluca ; Dagnelie, Gislin ; Scribner, Dean A. ; De Juan, Eugene ; Humayun, Mark S. / Retinal prosthesis for the blind. In: Survey of Ophthalmology. 2002 ; Vol. 47, No. 4. pp. 335-356.
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