Retinal Nerve Fiber Layer Thickness in Amblyopic Eyes

Michael X. Repka, Raymond T. Kraker, Susanna M. Tamkins, Donny W. Suh, Nicholas A. Sala, Roy W. Beck

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Purpose: To compare the peripapillary retinal nerve fiber layer (RNFL) thickness of amblyopic and fellow eyes. We hypothesized that the RNFL of the amblyopic eye may be thinner. Design: Prospective, cross-sectional, observational case series. Methods: Optical coherence tomography of the peripapillary RNFL thickness of amblyopic and fellow eyes was performed in 37 patients 7 to 12 years of age (mean age ± standard deviation, 9.2 ± 1.5 years) with unilateral strabismic, anisometropic, or combined-mechanism amblyopia enrolled in a randomized treatment trial. Results: Mean global RNFL thickness of the amblyopic and fellow eyes was 111.4 and 109.6 μm, respectively (mean difference, 1.8 μm thicker in the amblyopic eyes; 95% confidence interval, -0.6 to 4.3 μm). The amblyopic eye was 8 μm or more thicker than the fellow eye in 9 patients (24%); the fellow eye was 8 μm or more thicker than the amblyopic eye in 2 patients (5%); and the difference was within test-retest variability (7 μm) in 26 patients (70%). Conclusions: Our findings do not indicate that peripapillary RNFL thickness is thinner in eyes with moderate amblyopia compared with their fellow eyes.

Original languageEnglish (US)
Pages (from-to)143-147
Number of pages5
JournalAmerican journal of ophthalmology
Volume148
Issue number1
DOIs
StatePublished - Jul 1 2009

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Nerve Fibers
Amblyopia
Optical Coherence Tomography
Confidence Intervals

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Repka, M. X., Kraker, R. T., Tamkins, S. M., Suh, D. W., Sala, N. A., & Beck, R. W. (2009). Retinal Nerve Fiber Layer Thickness in Amblyopic Eyes. American journal of ophthalmology, 148(1), 143-147. https://doi.org/10.1016/j.ajo.2009.01.015

Retinal Nerve Fiber Layer Thickness in Amblyopic Eyes. / Repka, Michael X.; Kraker, Raymond T.; Tamkins, Susanna M.; Suh, Donny W.; Sala, Nicholas A.; Beck, Roy W.

In: American journal of ophthalmology, Vol. 148, No. 1, 01.07.2009, p. 143-147.

Research output: Contribution to journalArticle

Repka, MX, Kraker, RT, Tamkins, SM, Suh, DW, Sala, NA & Beck, RW 2009, 'Retinal Nerve Fiber Layer Thickness in Amblyopic Eyes', American journal of ophthalmology, vol. 148, no. 1, pp. 143-147. https://doi.org/10.1016/j.ajo.2009.01.015
Repka, Michael X. ; Kraker, Raymond T. ; Tamkins, Susanna M. ; Suh, Donny W. ; Sala, Nicholas A. ; Beck, Roy W. / Retinal Nerve Fiber Layer Thickness in Amblyopic Eyes. In: American journal of ophthalmology. 2009 ; Vol. 148, No. 1. pp. 143-147.
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