Retina-simulating phantom for optical coherence tomography

Jigesh Baxi, William Calhoun, Yasir Jamal Sepah, Daniel X. Hammer, Ilko Ilev, T. Joshua Pfefer, Quan Dong Nguyen, Anant Agrawal

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Optical coherence tomography (OCT) is a rapidly growing imaging modality, particularly in the field of ophthalmology. Accurate early diagnosis of diseases requires consistent and validated imaging performance. In contrast to more well-established medical imaging modalities, no standardized test methods currently exist for OCT quality assurance. We developed a retinal phantom which mimics the thickness and near-infrared optical properties of each anatomical retinal layer as well as the surface topography of the foveal pit. The fabrication process involves layer-by-layer spin coating of nanoparticle- embedded silicone films followed by laser micro-etching to modify the surface topography. The thickness of each layer and dimensions of the foveal pit are measured with high precision. The phantom is embedded into a commercially available, water-filled model eye to simulate ocular dispersion and emmetropic refraction, and for ease of use with clinical OCT systems. The phantom was imaged with research and clinical OCT systems to assess image quality and software accuracy. Our results indicate that this phantom may serve as a useful tool to evaluate and standardize OCT performance.

Original languageEnglish (US)
Article number021106
JournalJournal of Biomedical Optics
Volume19
Issue number2
DOIs
StatePublished - Jan 1 2014

Fingerprint

retina
Optical tomography
tomography
Surface topography
topography
Ophthalmology
ophthalmology
Imaging techniques
Medical imaging
Spin coating
assurance
silicones
Silicones
Quality assurance
Refraction
Image quality
coating
refraction
Etching
Optical properties

Keywords

  • Phantoms
  • optical coherence tomography
  • optical coherence tomography measurements
  • tissue-mimicking phantoms

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Baxi, J., Calhoun, W., Sepah, Y. J., Hammer, D. X., Ilev, I., Joshua Pfefer, T., ... Agrawal, A. (2014). Retina-simulating phantom for optical coherence tomography. Journal of Biomedical Optics, 19(2), [021106]. https://doi.org/10.1117/1.JBO.19.2.021106

Retina-simulating phantom for optical coherence tomography. / Baxi, Jigesh; Calhoun, William; Sepah, Yasir Jamal; Hammer, Daniel X.; Ilev, Ilko; Joshua Pfefer, T.; Nguyen, Quan Dong; Agrawal, Anant.

In: Journal of Biomedical Optics, Vol. 19, No. 2, 021106, 01.01.2014.

Research output: Contribution to journalArticle

Baxi, J, Calhoun, W, Sepah, YJ, Hammer, DX, Ilev, I, Joshua Pfefer, T, Nguyen, QD & Agrawal, A 2014, 'Retina-simulating phantom for optical coherence tomography', Journal of Biomedical Optics, vol. 19, no. 2, 021106. https://doi.org/10.1117/1.JBO.19.2.021106
Baxi J, Calhoun W, Sepah YJ, Hammer DX, Ilev I, Joshua Pfefer T et al. Retina-simulating phantom for optical coherence tomography. Journal of Biomedical Optics. 2014 Jan 1;19(2). 021106. https://doi.org/10.1117/1.JBO.19.2.021106
Baxi, Jigesh ; Calhoun, William ; Sepah, Yasir Jamal ; Hammer, Daniel X. ; Ilev, Ilko ; Joshua Pfefer, T. ; Nguyen, Quan Dong ; Agrawal, Anant. / Retina-simulating phantom for optical coherence tomography. In: Journal of Biomedical Optics. 2014 ; Vol. 19, No. 2.
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