Resting-state brain connectivity after surgical and behavioral weight loss

Rebecca J. Lepping, Amanda S. Bruce, Alex Francisco, Hung Wen Yeh, Laura E. Martin, Joshua N. Powell, Laura Hancock, Trisha M. Patrician, Florence J. Breslin, Niazy Selim, Joseph E. Donnelly, William M. Brooks, Cary R. Savage, W. Kyle Simmons, Jared M. Bruce

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective Changes in food-cue neural reactivity associated with behavioral and surgical weight loss interventions have been reported. Resting functional connectivity represents tonic neural activity that may contribute to weight loss success. This study explores whether intervention type is associated with differences in functional connectivity after weight loss. Methods Fifteen participants with obesity were recruited prior to adjustable gastric banding surgery. Thirteen demographically matched participants with obesity were selected from a separate behavioral diet intervention. Resting-state functional magnetic resonance imaging was collected 3 months after surgery/behavioral intervention. ANOVA was used to examine post-weight loss differences between the two groups in connectivity to seed regions previously identified as showing differential cue-reactivity after weight loss. Results Following weight loss, behavioral dieters exhibited increased connectivity between left precuneus/superior parietal lobule (SPL) and bilateral insula pre- to postmeal and bariatric patients exhibited decreased connectivity between these regions pre- to postmeal (Pcorrected<0.05). Conclusions Behavioral dieters showed increased connectivity pre- to postmeal between a region associated with processing of self-referent information (precuneus/SPL) and a region associated with interoception (insula) whereas bariatric patients showed decreased connectivity between these regions. This may reflect increased attention to hunger signals following surgical procedures and increased attention to satiety signals following behavioral diet interventions.

Original languageEnglish (US)
Pages (from-to)1422-1428
Number of pages7
JournalObesity
Volume23
Issue number7
DOIs
StatePublished - Jul 1 2015

Fingerprint

Weight Loss
Parietal Lobe
Brain
Bariatrics
Cues
Obesity
Diet
Hunger
Seeds
Stomach
Analysis of Variance
Magnetic Resonance Imaging
Food

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Lepping, R. J., Bruce, A. S., Francisco, A., Yeh, H. W., Martin, L. E., Powell, J. N., ... Bruce, J. M. (2015). Resting-state brain connectivity after surgical and behavioral weight loss. Obesity, 23(7), 1422-1428. https://doi.org/10.1002/oby.21119

Resting-state brain connectivity after surgical and behavioral weight loss. / Lepping, Rebecca J.; Bruce, Amanda S.; Francisco, Alex; Yeh, Hung Wen; Martin, Laura E.; Powell, Joshua N.; Hancock, Laura; Patrician, Trisha M.; Breslin, Florence J.; Selim, Niazy; Donnelly, Joseph E.; Brooks, William M.; Savage, Cary R.; Simmons, W. Kyle; Bruce, Jared M.

In: Obesity, Vol. 23, No. 7, 01.07.2015, p. 1422-1428.

Research output: Contribution to journalArticle

Lepping, RJ, Bruce, AS, Francisco, A, Yeh, HW, Martin, LE, Powell, JN, Hancock, L, Patrician, TM, Breslin, FJ, Selim, N, Donnelly, JE, Brooks, WM, Savage, CR, Simmons, WK & Bruce, JM 2015, 'Resting-state brain connectivity after surgical and behavioral weight loss', Obesity, vol. 23, no. 7, pp. 1422-1428. https://doi.org/10.1002/oby.21119
Lepping RJ, Bruce AS, Francisco A, Yeh HW, Martin LE, Powell JN et al. Resting-state brain connectivity after surgical and behavioral weight loss. Obesity. 2015 Jul 1;23(7):1422-1428. https://doi.org/10.1002/oby.21119
Lepping, Rebecca J. ; Bruce, Amanda S. ; Francisco, Alex ; Yeh, Hung Wen ; Martin, Laura E. ; Powell, Joshua N. ; Hancock, Laura ; Patrician, Trisha M. ; Breslin, Florence J. ; Selim, Niazy ; Donnelly, Joseph E. ; Brooks, William M. ; Savage, Cary R. ; Simmons, W. Kyle ; Bruce, Jared M. / Resting-state brain connectivity after surgical and behavioral weight loss. In: Obesity. 2015 ; Vol. 23, No. 7. pp. 1422-1428.
@article{6e23ba135ce44824aa11b381dcbb857e,
title = "Resting-state brain connectivity after surgical and behavioral weight loss",
abstract = "Objective Changes in food-cue neural reactivity associated with behavioral and surgical weight loss interventions have been reported. Resting functional connectivity represents tonic neural activity that may contribute to weight loss success. This study explores whether intervention type is associated with differences in functional connectivity after weight loss. Methods Fifteen participants with obesity were recruited prior to adjustable gastric banding surgery. Thirteen demographically matched participants with obesity were selected from a separate behavioral diet intervention. Resting-state functional magnetic resonance imaging was collected 3 months after surgery/behavioral intervention. ANOVA was used to examine post-weight loss differences between the two groups in connectivity to seed regions previously identified as showing differential cue-reactivity after weight loss. Results Following weight loss, behavioral dieters exhibited increased connectivity between left precuneus/superior parietal lobule (SPL) and bilateral insula pre- to postmeal and bariatric patients exhibited decreased connectivity between these regions pre- to postmeal (Pcorrected<0.05). Conclusions Behavioral dieters showed increased connectivity pre- to postmeal between a region associated with processing of self-referent information (precuneus/SPL) and a region associated with interoception (insula) whereas bariatric patients showed decreased connectivity between these regions. This may reflect increased attention to hunger signals following surgical procedures and increased attention to satiety signals following behavioral diet interventions.",
author = "Lepping, {Rebecca J.} and Bruce, {Amanda S.} and Alex Francisco and Yeh, {Hung Wen} and Martin, {Laura E.} and Powell, {Joshua N.} and Laura Hancock and Patrician, {Trisha M.} and Breslin, {Florence J.} and Niazy Selim and Donnelly, {Joseph E.} and Brooks, {William M.} and Savage, {Cary R.} and Simmons, {W. Kyle} and Bruce, {Jared M.}",
year = "2015",
month = "7",
day = "1",
doi = "10.1002/oby.21119",
language = "English (US)",
volume = "23",
pages = "1422--1428",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Resting-state brain connectivity after surgical and behavioral weight loss

AU - Lepping, Rebecca J.

AU - Bruce, Amanda S.

AU - Francisco, Alex

AU - Yeh, Hung Wen

AU - Martin, Laura E.

AU - Powell, Joshua N.

AU - Hancock, Laura

AU - Patrician, Trisha M.

AU - Breslin, Florence J.

AU - Selim, Niazy

AU - Donnelly, Joseph E.

AU - Brooks, William M.

AU - Savage, Cary R.

AU - Simmons, W. Kyle

AU - Bruce, Jared M.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Objective Changes in food-cue neural reactivity associated with behavioral and surgical weight loss interventions have been reported. Resting functional connectivity represents tonic neural activity that may contribute to weight loss success. This study explores whether intervention type is associated with differences in functional connectivity after weight loss. Methods Fifteen participants with obesity were recruited prior to adjustable gastric banding surgery. Thirteen demographically matched participants with obesity were selected from a separate behavioral diet intervention. Resting-state functional magnetic resonance imaging was collected 3 months after surgery/behavioral intervention. ANOVA was used to examine post-weight loss differences between the two groups in connectivity to seed regions previously identified as showing differential cue-reactivity after weight loss. Results Following weight loss, behavioral dieters exhibited increased connectivity between left precuneus/superior parietal lobule (SPL) and bilateral insula pre- to postmeal and bariatric patients exhibited decreased connectivity between these regions pre- to postmeal (Pcorrected<0.05). Conclusions Behavioral dieters showed increased connectivity pre- to postmeal between a region associated with processing of self-referent information (precuneus/SPL) and a region associated with interoception (insula) whereas bariatric patients showed decreased connectivity between these regions. This may reflect increased attention to hunger signals following surgical procedures and increased attention to satiety signals following behavioral diet interventions.

AB - Objective Changes in food-cue neural reactivity associated with behavioral and surgical weight loss interventions have been reported. Resting functional connectivity represents tonic neural activity that may contribute to weight loss success. This study explores whether intervention type is associated with differences in functional connectivity after weight loss. Methods Fifteen participants with obesity were recruited prior to adjustable gastric banding surgery. Thirteen demographically matched participants with obesity were selected from a separate behavioral diet intervention. Resting-state functional magnetic resonance imaging was collected 3 months after surgery/behavioral intervention. ANOVA was used to examine post-weight loss differences between the two groups in connectivity to seed regions previously identified as showing differential cue-reactivity after weight loss. Results Following weight loss, behavioral dieters exhibited increased connectivity between left precuneus/superior parietal lobule (SPL) and bilateral insula pre- to postmeal and bariatric patients exhibited decreased connectivity between these regions pre- to postmeal (Pcorrected<0.05). Conclusions Behavioral dieters showed increased connectivity pre- to postmeal between a region associated with processing of self-referent information (precuneus/SPL) and a region associated with interoception (insula) whereas bariatric patients showed decreased connectivity between these regions. This may reflect increased attention to hunger signals following surgical procedures and increased attention to satiety signals following behavioral diet interventions.

UR - http://www.scopus.com/inward/record.url?scp=84933181051&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84933181051&partnerID=8YFLogxK

U2 - 10.1002/oby.21119

DO - 10.1002/oby.21119

M3 - Article

C2 - 26053145

AN - SCOPUS:84933181051

VL - 23

SP - 1422

EP - 1428

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 7

ER -