Responses of neurons in ventrolateral orbital cortex to noxious visceral stimulation in the rat

Kenneth A. Follett, Bret Dirks

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In pentobarbital-anesthetized rats, responses of single neurons in ventrolateral orbital cortex (VLO) to noxious visceral (colorectal distension, CRD) and cutaneous stimulation were recorded. Of 71 neurons identified on the basis of spontaneous activity, 44 responded to CRD. CRD caused inhibition of neuronal activity in 38, facilitation of activity in four and 'mixed' responses in two of these cells. Cutaneous receptive fields were identified in 31 CRD-responsive and 10 CRD-non-responsive neurons. Cutaneous receptive fields were large and bilateral. 25 CRD-responsive cells responded only to noxious cutaneous stimulation, six had wide dynamic range responses. Six CRD-non-responsive cells responded only to noxious stimuli, four had wide dynamic range responses. No VLO neuron responded only to innocuous stimuli. These data are consistent with involvement of VLO in visceral nociception, possibly in non-discriminative aspects of nociception.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalBrain Research
Volume669
Issue number2
DOIs
StatePublished - Jan 16 1995

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Prefrontal Cortex
Neurons
Skin
Nociception
Pentobarbital

Keywords

  • Colorectal distension
  • Nociception
  • Pain
  • Pentobarbital
  • Viscera

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Responses of neurons in ventrolateral orbital cortex to noxious visceral stimulation in the rat. / Follett, Kenneth A.; Dirks, Bret.

In: Brain Research, Vol. 669, No. 2, 16.01.1995, p. 157-162.

Research output: Contribution to journalArticle

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N2 - In pentobarbital-anesthetized rats, responses of single neurons in ventrolateral orbital cortex (VLO) to noxious visceral (colorectal distension, CRD) and cutaneous stimulation were recorded. Of 71 neurons identified on the basis of spontaneous activity, 44 responded to CRD. CRD caused inhibition of neuronal activity in 38, facilitation of activity in four and 'mixed' responses in two of these cells. Cutaneous receptive fields were identified in 31 CRD-responsive and 10 CRD-non-responsive neurons. Cutaneous receptive fields were large and bilateral. 25 CRD-responsive cells responded only to noxious cutaneous stimulation, six had wide dynamic range responses. Six CRD-non-responsive cells responded only to noxious stimuli, four had wide dynamic range responses. No VLO neuron responded only to innocuous stimuli. These data are consistent with involvement of VLO in visceral nociception, possibly in non-discriminative aspects of nociception.

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